The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
We are seeking a highly motivated postdoctoral researcher with experience in organic & medicinal chemistry and/or chemical biology to work in the laboratory of Alessio Ciulli at the Dundee’s School of Life Sciences, Division of Biological Chemistry and Drug Discovery, under the auspices of a new Protein Degradation Centre, on a project in close collaboration with the group of Dario Alessi at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU).
The goal of the project is to develop novel bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), for a challenging protein kinase target linked to disease.
For more information on the Ciulli and Alessi labs:
For further information on previous research on a) PROTAC development by the Ciulli group and b) collaborative PROTAC projects by the Ciulli/Alessi groups see:
(a) Zoppi et al. J. Med. Chem. 2019; b) Testa et al. Angew. Chem. Intl. Ed. 2020
(b) Tovell et al. ACS Chem. Biol. 2019, pp. 2024; b) Tovell et al. ACS Chem. Biol. 2019, pp. 882
Your priorities will include:
- Building on exciting preliminary data, the postholder will be expected to design, synthesise and characterise novel PROTACs as degraders of the target of interest in cellular and disease models.
- The ultimate ambition is to qualify potent, selective and cell-active degraders as tool compounds to investigate the target's biology and as starting points for potential therapeutic development.
We are looking for candidates with:
- A Ph.D. in the chemical or pharmaceutical sciences, or a related discipline
- Strong background in chemical biology and/or organic/medicinal chemistry. Experience with targeted protein degradation will be a plus but is not required.
- Excellent interpersonal, communication and presentation skills
- An open and collaborative approach to science
- Outstanding academic or industrial track record
- Capable of working in a diverse team, but able to plan and work independently
- Exceptional time management, organisational and self-motivational skills
The post is available for 12 months in the first instance.
Appointment on the Grade 7 salary scale (£32,817 - £40,322) is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD, and in this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (£29,176 - £31,866).
The Biological Chemistry and Drug Discovery Division operates on an external funding basis. The Principal Investigators within this unit are highly successful in securing external funding for their multi-disciplinary and highly collaborative research and activities.
The new Protein Degradation Centre is part of a growing Life Sciences Innovation District, an ecosystem of organisations and people within the life sciences sector in Dundee driving innovation and local economic growth. The Centre has a track record of redefining new models of research in translational chemical biology, such as innovative academia-industry collaborations (Boehringer Ingelheim, Eisai) and spin-out companies (Amphista therapeutics).
The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk). The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies.
The Protein Degradation Centre and the MRC-PPU are located in a beautiful setting overlooking the estuary of the River Tay. They are embedded within the University of Dundee’s School of Life Sciences, one of the premier research centres in the world recently assessed as the top UK University for Life Sciences research in the 2014 Research Excellence Framework (REF). The University of Dundee main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. http://www.lifesci.dundee.ac.uk/
The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.