Summary of Job Purpose and Principal Duties:
Applications are invited for two Michael J. Fox Foundation funded postdoctoral positions within the MRC Protein Phosphorylation and Ubiquitylation Unit to uncover molecular pathways involved in Parkinson’s disease. The work will be centred around identifying and characterising ubiquitin E3 ligases and deubiquitylases involved in the degradation of mitochondria (in the laboratory of Dr. Ian Ganley) or alpha-synuclein (in the laboratory of Dr. Gopal Sapkota). We are seeking talented and highly motivated individuals to characterise these key pathways in the hopes of better understanding disease pathology and to open up potential new therapeutic avenues. The successful applicants will deploy a state-of-the-art blend of techniques including high content imaging, gene editing, biochemical and proteomic assays.
Positions are available from November 2020, and are fixed-term for 24 months.
- PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
- Strong background in cell biology and high throughput screening would be beneficial.
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and knowledge of the English language.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 25 - 28 £29,176 - £31,866).
How to apply:
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):
The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk) and has an exciting and collaborative research environment, equipped to the highest international standards. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is located in a beautiful setting overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee. This is one of the premier Life Sciences research centres in the world and was recently assessed as the top UK University for Life Sciences research in the 2014 Research Excellence Framework (REF).
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.