The Drug Discovery Unit (www.drugdiscovery.dundee.ac.uk) is a dynamic and multidisciplinary group of 95 scientists with expertise in structural biology, compound handling, assay development, high-throughput screening, medicinal and computational chemistry and in vitro and in vivo pharmacokinetics. The unit is housed in a state-of-the-art building and has cutting-edge equipment and automation, including an in-house X-ray diffractometer.
We are seeking an experienced and motivated crystallographer to work on a fragment-based drug discovery project working to generate novel therapeutic agents. This will primarily involve protein crystallisation and co-crystallisation/ soaking. There will also be some elements of assay development and compound design. The successful applicant will be part of an interdisciplinary team including medicinal chemists and cell biologists. The post is available immediately for 2 years.
• A PhD with a large component of protein structural biology using X-ray crystallography or a BSc in Biochemistry or an appropriate degree followed by experience in carrying out X-ray crystallography.
• Hands on experience of protein crystallography with a demonstrable understanding of the range of protein constructs desired/required to support projects.
• Understanding of protein-ligand interactions.
• Experience in obtaining protein:ligand complexes
• Excellent problem solving and creative thinking abilities.
• Good interpersonal skills.
• The ability to work in teams, and to work to timelines and deliver milestones.
• Self-motivated, able to work independently with minimal direction/oversight.
• Experience of fragment-based drug discovery.
• Understanding of the drug discovery process
A few facts about The School of Life Sciences at Dundee
• The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.
• The School of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.
Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee is also a vibrant cultural centre. Home to the new V&A Dundee, opened in September 2018 and already hosting its 500,000th visitor; the Dundee Rep and Scottish Dance Theatre; Dundee Contemporary Arts; MacManus Gallery and many individual artists.
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The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.