University of Dundee

Senior Postdoctoral Scientist

Unit: 
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
SLSC0599
Closing Date: 
Friday, June 28, 2019
Salary: 
Grade 8 (£40,792 - £48,677)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Applications are invited for a senior postdoctoral position in the Laboratory of Dr. Yogesh Kulathu to study the mechanisms by which T cell biology and immune responses are regulated by the ubiquitin system. We are seeking enthusiastic and motivated individuals with a strong background in immunology, cell biology and biochemistry to undertake exciting and cutting-edge research aimed at unravelling pathways and mechanisms by which cells maintain proteostasis.

The Kulathu lab uses a multidisciplinary approach in their research and employ techniques ranging from X-ray crystallography and biophysics, to yeast genetics and cell biology. The aims of the projects available in the lab are to explore the functional roles of components of the ubiquitin system in regulating T cell function. We are also interested in investigating underlying mechanisms using genetic screens, reconstitution systems and in vivo reporter models that the successful candidate will develop and apply during this project.

Candidates with extensive experience in the following areas are essential for this position: ubiquitylation and ubiquitin-like modifiers and lymphocyte development and signalling. The candidate should have a strong academic track record, background and extensive experience in immunology, mouse biology, yeast-two-hybrid screening, enzymology, monoclonal antibody purification, flow cytometry and biochemistry. Proficiency in advanced imaging techniques including confocal and electron microscopy will also be advantageous. The successful candidate will have extensive experience of mouse colony management and of animal models of infection, immunisation, and autoimmune disease, as well as ex vivo assays for lymphocyte development and function including foetal thymus organ cultures. It is expected that the candidate will develop and apply a broad range of techniques to pursue the research objectives and work on multiple projects. The successful candidate will interact with postdocs and students in the lab to mentor and provide supervision and support. The project will involve using the cutting-edge facilities in biochemistry, cell biology, in vivo models, high-resolution microscopy and proteomics available within the School of Life Sciences.

University Statement:

https://www.dundee.ac.uk/research/governance-policy/policyroadmap/statement-on-use-of-animals/

This position is available Full-Time, Fixed Term until 31 March 2023 in the first instance. Informal enquiries may be directed to ykulathu@dundee.ac.uk

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.

Candidate requirements:

• PhD (or final stages of PhD) in a relevant biological subject with research experience in protein biochemistry and cell biology or proteomics.

• Strong academic track record with at least one good quality first author publication in peer-reviewed journals.

• Ability to work independently, but capable of interacting well within a group

• Excellent communication skills and proficiency in English

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

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The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.