General description of the Network:
The Tripartite motif (TRIM) family of Ubiquitin E3 ligases plays an important role in many physiological processes and in many diseases including cancer, neurodegenerative and neuro-muscular disorders and rare genetic diseases. As such, they are excellent targets for therapeutic manipulation. TRIM-NET is a training programme for Early-Stage Researchers to identify novel therapeutic targets and to develop the strategies to validate them in preclinical studies. The TRIM-NET network will integrate complementary expertise and multidisciplinary approaches to exploit common targeting strategies for translational applications. The consortium will train a cohort of young researchers in skills and expertise essential for biomedical research focusing on: i) determining how TRIM proteins contribute to disease; ii) developing strategies to modulate TRIM protein activity; iii) designing high throughput screening assays for drug discovery. As the scientific work packages are highly integrated, recruited students will avail of techniques and training opportunities, including secondments, across the work packages. Through a unique international partnership between academic and non-academic partners the TRIM-NET training programme will provide young researchers with skills required for biomedical research in industry and academia.
Summary of the Project:
Arsenic is used therapeutically to treat Acute Promyelocytic Leukaemia by inducing SUMO-dependent, ubiquitin-mediated degradation of the PML-RAR oncoprotein. The objective of the work will be to define the mechanism by which arsenic induces SUMO modification of PML (TRIM19) and will involve a combination of biochemical, proteomic and structural biology approaches.
The project will last 36 months. Students are expected to initiate their contracts between 1 June 2019 and 1 November 2019 depending on the PhD enrollment rules.
Eligibility and Requirements:
• Not having a doctoral degree yet
• Less than 4 years full-time research experience
• A degree which entitles to embark on a doctorate in the host countries
• Less than 12 months spent in the host country in the 3 years prior to the recruitment
• A strong background in Biology, Biochemistry, Chemistry, Medicine or related fields according to the individual research projects
• The relevant PhD accession title should be achieved by June 2019 through September 2019 according to the specific PhD programmes and countries
Job offer and Benefits:
• Attractive salary. EUR 40,945 - EUR 44,840 per annum. The exact salary will be calculated in GBPs and will contemplate living and mobility allowances.
• 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations for Early Stage Researchers;
• Enrollment in a PhD programme at the local partner’s institution. In case the student is enrolled in a doctoral programme in a country where the duration of the PhD study is beyond the 3-year-MSCA contract, additional funding for the additional year(s) will be provided by the host group
• Access to state-of-the-art research and supervision by recognized experts
• Participation in network-wide training activities, schools and conferences
• Secondments periods at other network partners’ labs.
Applications in English should include:
• A cover letter indicating the top three projects of election in the order of preference (see below) and the indication of the countries of residence during the last 3 years;
• CV (contact details, education, work experience, list of publications, prizes/awards, language skills, etc….);
• A motivation letter;
• A digital copy of the degree certificate and official academic transcripts of Bsc and Msc studies (Master diploma/certificate or equivalent qualification giving access to the Doctoral Programme + Transcript of Records including examinations and scores obtained. If the documents are issued in a language other than English, a translation must be included, along with the original document);
• A documentation of English language qualifications;
• Two recommendation letters sent directly by the referees to firstname.lastname@example.org with the subject: “Letter concerning - Surname Name” and full contact details of the reference persons;
Application in a single pdf file should be sent by e-mail to email@example.com with indication of “TRIM-NET application” in the subject line. Equal consideration will be given to female and male applicants.
Applications and enquiries should be made to firstname.lastname@example.org. Applications must NOT be made via the University of Dundee website.
Deadlines of Application, Evaluation process and Starting date:
• Deadline for Application: 15 April 2019.
• The merit-based recruitment process will be on a competitive basis across all applicants for each project.
• Short-listed students will be interviewed via Skype on 9-10 May 2019.
• Students are expected to initiate their contracts between 1 June 2019 and 1 November 2019 depending on the PhD enrollment rules of the different countries.
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.