University of Dundee

Research Technician (0.5 FTE)

Centre for Gene Regulation and Expression
Job Reference: 
Closing Date: 
Thursday, January 31, 2019
Grade 5 (£22,017 - £25,482)

Research Technician position to support the Drosophila work to study O-GlcNAc signalling pathways linked to development and neurodegeneration in the laboratory of Professor Daan van Aalten FRSE.

Applications are invited for a research technician position to work in the multidisciplinary laboratory of Daan van Aalten, where we aim to elucidate fundamental mechanisms of the O-GlcNAc posttranslational modification in development and neurodegeneration. This position is funded by a prestigious 5-year Investigator Award from the Wellcome Trust. The van Aalten lab has a major interest in how O-GlcNAcylation controls protein function. We use CRISPR/Cas9 and pharmacological approaches in Drosophila to study the mechanisms of how O-GlcNAc controls patterning of the early embryo and the nervous system.

The successful applicant will provide critical services for the lab's research conducted with the fruit fly. After training, the Research Technician will perform basic fly genetics, including setting up crosses for creating new CRISPR/Cas9 Drosophila lines, balancing stocks and screening for markers. The person will be responsible for upkeep of the the DvA Lab’s fly stock collection and general day to day fly room maintenance such as preparation of non-standard fly food and recycling of vials.

This position is available for 12 months at 50% part time in the first instance. Starting date February/March 2018.

Candidate requirements:


- Having sufficient management and Drosophila experience to organize the laboratory fly lines and perform basic fly genetics.

- Familiarity with basic laboratory techniques such as DNA and RNA extraction, PCR, gel electrophoresis and Western blots.

- Good manual dexterity and ability to perform delicate collection actions.

- Capable of working in a team, but able to plan and work independently.

- Excellent communication skills to coordinate with lab members.

- Ability to follow specific protocols and verbal direction.

- Mathematical ability as needed to accurately execute and modify recipes according to volume needed.

- Good organizational and time management skills.

- Willingness to assist and communicate with other team members of the laboratory.


- A background in working with Drosophila as a model of animal development.

- Experience with microinjection

- Having knowledge of analyzing fly lines by standard molecular biology and biochemistry techniques such as DNA and RNA extraction, PCR, and Western blotting.

For informal enquiries please contact Daan van Aalten ( For details on the van Aalten lab please visit our website

The van Aalten lab is based in the Centre for Gene Regulation and Expression and is an exciting and collaborative research environment, equipped to the highest international standards. The School of Life Sciences is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee. This is one of the premier Life Sciences research centres in the world and was recently assessed as the top UK University for Life Sciences research in the 2014 Research Excellence Framework (REF).

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