University of Dundee

Postdoctoral Research Scientist

Unit: 
Centre for Gene Regulation and Expression
Job Reference: 
SLSC0429
Closing Date: 
Thursday, July 12, 2018
Salary: 
Grade 8 (£39,992 - £47,722)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We are seeking an experienced and highly motivated Postdoctoral Research Scientist to join the School of Life Sciences Laboratory for Quantitative Proteomics, working with Professor Angus Lamond on a collaborative project funded by the Wellcome Trust. The aim of the project is the identification and characterisation of novel substrates of human prolyl hydroxylases to aid our understanding of the mechanism of action of PHD inhibitors for the treatment of kidney clear cell carcinoma. Applicants must have a proven track record of expertise in mass spectrometry and proteomics and experience with the analysis of post-translational protein modifications is desirable.



Mass spectrometrist/Proteomicist

The successful candidate should be a self-motivated, enthusiastic and skilled research scientist, with a first degree in either physical sciences (Chemistry/Physics/Chemical Engineering) or Biochemistry/Molecular Biology and a PhD (or equivalent degree) in mass spectrometry/proteomics. Previous postdoctoral experience in mass spectrometry/proteomics would be an advantage. The successful candidate will participate in an interdisciplinary project, working together with biochemists and cell biologists from the collaborating research groups.

The successful candidate will contribute to the analysis of PHD substrates and play a leading role in the analysis of hydroxy-proline modifications on target proteins using quantitative mass spectrometry. They will contribute to improving methods for the reliable identification and quantification of both unmodified and hydroxy-proline modified and phosphorylated peptides. Therefore, prior experience with the analysis of post-translational protein modifications isolated from complex cell and tissue samples will be an advantage.

Previous experience in all relevant areas of biological mass spectrometry for proteomics, including sample preparation, chromatography, mass spectrometry and data processing is desirable. In different parts of the project the candidate will be required to work both independently and as part of a larger team and good communication skills are essential. Prior experience in working on a multi-laboratory, interdisciplinary project would therefore be an advantage.

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations.



The position will be appointed for an initial period of three years Full Time. Salary will be in the range £39,992 - £47,722, dependent upon prior experience.

 

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The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.