We seek a highly motivated and versatile cell biologist with significant experience in developing cellular assays to support drug discovery programs and to investigate target biology and disease relevant mechanisms. The successful candidate will join a multi-disciplinary team of scientists engaged in an exciting drug discovery collaboration between Professor Alessio Ciulli (http://www.lifesci.dundee.ac.uk/people/alessio-ciulli-0) and Boehringer Ingelheim. Our mission is to discover and develop a class of small-molecule drugs for targeted protein degradation as a novel therapeutic paradigm to treat cancer and other human diseases with serious unmet medical needs.
The collaboration is centred on the design, synthesis and evaluation of a revolutionary new class of molecular therapeutics known as proteolysis targeting chimeric molecules (PROTACs). A PROTAC is a bifunctional compound that contains two ligands connected by a linker unit. One ligand binds to an E3 ubiquitin ligase complex while the other ligand binds to a target protein of interest, thus triggering the poly-ubiquitination and subsequent proteasome-dependent degradation of the target protein. Following a successful start to the collaboration, we are now expanding our team in order to accelerate the translation of research in this field into therapeutic reality.
The post is available to start on 1st September 2018 and salary will depend on experience, but will be up to £38,833. This is a unique opportunity to gain experience and drive forward innovation in world-leading industry-style drug discovery within an academic setting. The position is available for 24 months.
• Developing relevant, novel and innovative cell-based and biochemical assays to address project challenges and support drug discovery projects
•Applying these assays to screen and profile cellular activity of novel compounds and to interrogate target biology/disease relevant mechanisms
•Culturing human cell lines and use modern technologies to generate new cell lines
•Carrying out data analysis and relevant quality assurance protocols
•Develop team science across the collaboration, working with colleagues across disciplines to enable breakthroughs.
•Assist in all aspects of building the biology relevant research capabilities of the team
•Present at group meetings
•Report directly to the Team Leader and to the Principal Investigator (Professor Ciulli)
Your qualifications and skills:
•A PhD in molecular cell biology, biochemistry, chemical biology or a related discipline is required.
•Prior experience in oncology drug discovery preferred but not essential
•Outstanding academic or industrial track records are strongly desired
•Strong background in cell biology, molecular biology and biochemistry techniques is required
•Proven competence in culturing cells in Category 2 facilities is essential
•Experience with shRNA and CRISPR and other relevant genome editing technologies will be a plus
•A demonstrated ability to problem solve and innovate within a team environment
•Strong interpersonal, communication and presentation skills are essential
•Experience designing assays for the detection of protein degradation would be an advantage
Appointment on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In those cases the initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
Informal enquiries may be made to Professor Alessio Ciulli, e-mail: firstname.lastname@example.org
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