Control of DNA repair in health and disease
MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
The Rouse lab is interested in how cells sense, signal and repair damaged DNA, and how they cope when DNA damage – or other obstacles – blocks the process of DNA replication. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Disrupting DNA repair causes human disease, and yet inhibiting DNA repair pathways acutely is an important way of killing tumours. In this light, several of the most commonly used chemotherapeutic agents kill tumours by inducing DNA damage.
Applications are invited from bright enthusiastic individuals to explore the molecular mechanisms keeping the activity of the SLX4 complex in check. The SLX4 complex is like a molecular Swiss army knife, with several nucleases acting like molecular blades for cleaving DNA in a programmed manner during DNA repair. Mutations in SLX4 in mammals causes a range of diseases. A range of approaches – biochemistry, genetics and cell biology – will be used to tackle the question we are trying to answer. The position, which is funded by the Medical Research Council (MRC), is for 3 years with the possibility of extension.
The Rouse lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation. The Unit has state-of-the-art facilities and services including dedicated cloning, protein production and antibody production teams, making more time for research.
Summary of Skills, Experience and Qualifications
· PhD with excellent academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
· Ability to work as part of a team, but able to plan and work independently
· Excellent communication skills and proficiency in English
· A background in biochemistry, molecular biology and analysis of DNA repair in eukaryotes is desirable
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
College / School / Directorate Information
Informal enquiries should be directed to Prof. John Rouse at email@example.com
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