DNA repair helicases in health and disease
MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
The Rouse lab is interested in mechanisms underlying the repair of damaged DNA, and how defects in DNA repair cause human disease. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Disrupting DNA repair causes human disease, and yet inhibiting DNA repair pathways acutely is an important way of killing tumours. In this light, several of the most commonly used chemotherapeutic agents kill tumours by inducing DNA damage.
The Rouse lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation. The Unit has state-of-the-art facilities and services including dedicated cloning, protein production and antibody production teams, making more time for research.
Applications are sought for a postdoctoral position which involves investigating the roles of poorly characterized DNA helicases in repairing the kinds of DNA damage inflicted by chemotherapeutic agents, and the relevance of these helicases to human disease. The position is for 2 years in the first instance.
Summary of Skills, Experience and Qualifications
College / School / Directorate Information
Informal enquiries should be directed to Prof. John Rouse at firstname.lastname@example.org
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The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.