DNA repair helicases in health and disease
MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
The Rouse lab is interested in mechanisms underlying the repair of damaged DNA, and how defects in DNA repair cause human disease. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Disrupting DNA repair causes human disease, and yet inhibiting DNA repair pathways acutely is an important way of destroying tumours. In this light, several of the most commonly used chemotherapeutic agents destroy tumours by inducing DNA damage.
The Rouse lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation. The Unit has state-of-the-art facilities and services including dedicated cloning, protein production and antibody production teams, making more time for research.
Applications are sought for a postdoctoral position which involves investigating the roles of poorly characterized DNA helicases in repairing the kinds of DNA damage inflicted by chemotherapeutic agents, and the relevance of these helicases to human disease. The position is for 2 years in the first instance.
Summary of Skills, Experience and Qualifications
· PhD with excellent academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
· Ability to work as part of a team, but able to plan and work independently
· Excellent communication skills and proficiency in English
· A background in biochemistry, molecular biology and analysis of DNA repair in eukaryotes is desirable
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
College / School / Directorate Information
Informal enquiries should be directed to Prof. John Rouse at email@example.com
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