University of Dundee

Postdoctoral Research Assistants (Genome Integrity and Chromosome Biology)

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
Closing Date: 
Friday, June 2, 2017
Grade 7 (£31,076 - £38,183)

Postdoctoral positions are available in the Laboratory of Professor Karim Labib, to study the mechanisms and regulation of chromosome replication in eukaryotic cells. The successful applicants will design and carry out independent research projects in a dynamic and highly interactive research group. Further details of our work can be found at

Project summary:
Karim Labib’s group studies the regulation and mechanisms of action of the eukaryotic replisome. Our work ranges from biochemical reconstitution of replication with purified proteins, to genetics and cell biology. We use the budding yeast Saccharomyces cerevisiae to address the fundamental principles of eukaryotic chromosome replication, together with the early embryo of the nematode Caenorhabditis elegans to study the regulation of the replisome in metazoa. We are also using the power of CRISPR-Cas9 genome editing to develop new models for studying the mammalian replisome.

New projects might include (but are not limited to):
- Studying the mechanism and regulation of DNA replication termination in yeast and metazoa
- Structural characterisation of the enzymes that mediate CMG helicase disassembly
- New mitotic pathways for replisome disassembly
- Studying the regulation of the replisome by checkpoint kinases

The positions are available for 3 years.

Informal enquiries can be made to Karim Labib (

Candidate requirements:
• PhD or in final stages of PhD submission
• Strong academic track record, with publications (or manuscripts near submission) in peer-reviewed journals
• Evidence of data presentation at scientific meetings
• Ability to work independently and also capable of interacting well within a group

• Experience of protein biochemistry / yeast biology / C. elegans biology / or genome editing of mammalian cells
• Development of sophisticated biochemical assays

Postdoctoral fellows are expected to lead their own projects, contribute to other projects on a collaborative basis, and help with guiding PhD students in their research. The ability to work well in a team is essential.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD.

MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) and School of Life Sciences:
These projects will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit, based within the School of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation ( The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, and to generate reagents and improve technologies. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and is embedded within the School of Life Sciences at the University of Dundee, which is one of the premier research centres for Life Sciences, and has a particular strength in the area of genome integrity.


How to apply:

To apply on-line click here.


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The University of Dundee has received the Athena SWAN Bronze Award ( which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.


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