Subject Area: Regulation of dynamic transcriptome changes
Applications are invited for a post-doctoral position funded by the BBSRC until 31 March 2020. We are looking for an enthusiastic and motivated post-doctoral scientist to investigate how changes in the transcriptome of Arabidopsis are regulated in response to low temperature.
Gene expression is regulated at the levels of transcription and alternative splicing (AS). The extent to which AS impacts plant development and responses to external cues is poorly characterised. We focus on the response of plants to low temperature and the role of the circadian clock in modulating expression. We use state-of-the-art methods to analyse gene expression at the transcript and AS levels. The aims of this project are to dissect the rapid and dynamic changes in AS immediately following application of low temperature; to investigate the role of the clock in changes in rhythmic expression; to address mechanisms which control these changes; and to construct and test splicing networks. The project will use of RNA-sequencing and proteomics of time-course experiments of plants grown under different temperature and circadian conditions; subsequent investigations to characterise key regulatory genes will use molecular and biochemical techniques.
Essential: A PhD demonstrating a solid background in molecular biology; ability to work in a team, but able to plan and work independently; excellent communication skills and knowledge of the English language.
Desirable: Strong interests or expertise in RNA biology, gene expression and alternative splicing, circadian clock; experience in bioinformatics, statistics, working with plants
The position is in the laboratory of Professor John Brown at the University of Dundee School of Life Sciences; Division of Plant Sciences - http://www.lifesci.dundee.ac.uk/ps) based at the James Hutton Institute - the largest plant breeding and research institute in Scotland with particular expertise in translational plant science. The project is a collaboration with Professor Hugh Nimmo (University of Glasgow) and Professor Katherine Denby (University of York).. The post-holder will interact closely with the team of scientists involved in the project including a molecular biologist in Glasgow, a computational biologist/bioinformatician at the James Hutton Institute and computational biology PhD students. The ability to work well in a team is an important requirement of this post.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,175).
How to apply:
To apply on-line click here.
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