A new post has been created in the University of Dundee Drug Discovery Unit (DDU) (www.drugdiscovery.dundee.ac.uk/) to provide biophysical assay support to target-based drug discovery programmes across all portfolios. This includes neglected tropical diseases, TB and diseases of the developed world.
The Drug Discovery Unit is part of the Wellcome Centre for Anti-Infectives Research and is a dynamic and multidisciplinary group with expertise in compound handling, assay development, high-throughput screening, medicinal and computational chemistry and in vitro and in vivo pharmacokinetics. The unit is housed in a state-of-the-art building and has cutting-edge equipment and automation for hit-discovery.
Available for 3 years in the first instance, the post holder will be part of the DDU’s Structure-Driven Drug Discovery Group. The post will involve:
- SPR (surface plasmon resonance) assay development for target-based drug discovery programmes.
- Routine SPR profiling of programme compounds.
- Development/profiling in alternate biophysical assays (biolayer interferometry, isothermal titration calorimetry, thermal shift).
- Providing biophysical expertise to support progression of projects.
- Regular interactions with a team of biochemists, medicinal chemists, structural biologists and DMPK scientists.
The successful candidate will be expected to:
- Design and perform experiments, follow protocols meticulously and report results, both verbally and in writing, within agreed timelines.
- Maintain detailed, industry-standard, electronic records of all experiments.
- Assist with routine maintenance and troubleshooting of instruments and laboratory housekeeping functions.
- Comply with Health and Safety practices within the Unit.
- Candidates are expected to have a degree in Biochemistry or Pharmacology (or other appropriate life science discipline).
- Expertise developing SPR assays.
- Understanding of enzyme kinetics.
- Experience with curve-fitting, data handling and analysis.
- High level of attention to detail.
- Strong organisational skills including ability to prioritise.
- Ability to work to tight deadlines and rigorous standards.
- Flexible approach to projects; priorities may change based on overall portfolio needs and strategy.
- Good interpersonal / communication skills.
- Ability to work independently and as part of a team.
- Knowledge of the drug discovery process with a particular focus on the hit-discovery stage.
- Expertise with other biophysical techniques (isothermal titration calorimetry, biolayer interferometry, thermal shift).
In the medium term the applicant will expected to contribute to the overall portfolio by identifying and assessing potential new approaches and projects. Opportunities are available for continuing education, conference attendance and scientific publishing, so career development opportunities will be available for the right candidate.
For informal enquiries please contact Manu De Rycker (firstname.lastname@example.org)
The post is available immediately for 3 years, initially. The starting salary for this post will be within Grade 6 (£25,298 - £31,076) depending on the experience of the candidate. A relocation allowance is available.
How to apply:
To apply on-line please click here.
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.
The University of Dundee has received the Athena SWAN Bronze Award (http://www.dundee.ac.uk/about/athenaswan/) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.