Applications are invited for the above vacancy to work in the laboratory of Kris Clark on a project aimed at unraveling the molecular networks that promote the resolution of inflammation. The lab has recently identified a key role for the SIK family of protein kinases in regulating the phenotypic switch of macrophages from a pro-inflammatory to an anti-inflammatory state (Clark et al. PNAS 2012, 109, 16986-16991; Ozanne et al. Biochem J 2014, in press). The remarkable effects of small-molecule inhibitors of the SIKs on macrophage biology have identified these enzymes as attractive targets for the development of improved anti-inflammatory drugs. We are seeking a talented scientist whose research will lead to a greater understanding of the molecular mechanisms by which the SIKs control macrophage function. The person appointed will use state-of-the-art technologies in cell signaling, chemical biology, mass spectrometry and (phospho)proteomics to study SIK biology in primary cells from mice expressing inactive mutants of SIKs that we have recently generated.
This is a fixed-term post until 31st March 2018.
The successful candidate will be energetic and highly motivated with excellent interpersonal, organizational and communication skills. They will have an outstanding academic track record, hold a PhD in biochemistry, immunology or related discipline and have published in internationally recognized peer-reviewed journals. Preference will be given to candidates with a strong background in biochemistry, molecular and cellular biology. Experience in exploiting animal models of disease would be an advantage.
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):
This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee which is one of the premier Life Sciences research Centres in the world.
For further information on the research activities of the lab, please refer to our website at http://www.ppu.mrc.ac.uk/research/?pid=1013.
It is anticipated that interviews will be held during week commencing 5th January 2015.
Informal enquiries should be directed to Dr. Kris Clark (firstname.lastname@example.org).
How to apply:
To apply on-line click here.