University of Dundee

Postdoctoral Research Assistants

Division of Signal Transduction Therapy (DSTT)
Job Reference: 
Closing Date: 
Tuesday, May 1, 2012
Grade 7 (£29,249 - £35,938)

Postdoctoral positions and PhD studentships in the world’s largest collaboration between academia and the pharmaceutical industry

The Medical Research Council and the University of Dundee have obtained renewed funding from July 2012-2016 for  the Division of Signal Transduction Therapy (DSTT) a unique collaboration between scientists in the MRC Protein Phosphorylation  Unit and the College of Life Sciences at the University of Dundee and six of the world's leading pharmaceutical companies. The DSTT is dedicated to accelerating the development of specific inhibitors of signal transduction for the treatment of disease, as well as for the study of cell signaling. It involves 17 laboratories comprising approximately 200 scientific and support staff and is one of the world’s largest ever collaborations between the pharmaceutical industry and an academic centre.

A number of Postdoctoral positions and studentships are available to work in the research field of the collaboration, which is “kinases and the ubiquitin system”. 

We also have a number of postdoctoral positions to work for 2-3 month periods on diverse projects of mutual interest to DSTT laboratories and collaborating companies. These posts are relevant to potential candidates interested in working on applied projects rather than basic research.

The participating laboratories are (Click on investigator to gain access to their research web pages that detail research projects that are on going in each laboratory)

Dario Alessi Understanding the functions of kinases and ubiquitylation pathway components mutated in inherited disorders 
Gabriella Alexandru Exploration of the p97 and UBX-Protein Interaction Networks and Identification of Novel p97 Targets 
Arno Alpi ubiquitin-signaling pathways that regulate cellular responses to DNA damage
Simon Arthur Signalling in the Immune System 
Doreen Cantrell Signaling pathways that control effector and regulatory gut lymphocytes" 
Vicky Cowling Synthesis, function and therapeutic potential of the mRNA methyl cap 
Philip Cohen The Interplay Between Protein Phosphorylation and Protein Ubiquitylation in Regulating Innate Immunity 
Ian Ganley Molecular regulation of autophagy in health and disease 
Grahame Hardie Understanding the importance of AMPK signalling pathway in Cancer 
Ronald Hay Understanding Sumo biology 
Thimo Kurz Function and regulation of Cullin-based E3 Ubiquitin Ligases 
Carol Mackintosh 14-3-3-binding phosphoproteome in cancer and brain metabolism
Patrick Pedrioli Development and application of methodologies for proteomics analysis of ubiquitin like modifiers 
Gopal Sapkota Understanding TGFβ/BMP signal transduction pathways in cells and human diseases 
John Rouse Forks and molecular knives at the cutting edge of DNA repair 
Matthias Trost Development of new mass spectrometry technology to accelerate analysis of protein phosphorylation 
Satpal Virdee Development of tools for advancing our understanding of the ubiquitin system

Postdoctoral appointments will be made on the University’s salary scale according to achievements and experience. Successful candidates may start at any time between July 2012 to June 2013. PhD studentships would be appointed to our MRC Unit PhD Prize Studentship programme (For further details see

To apply on-line please click here.  If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack.  Please quote reference number LS0168.  The closing date for applications is 1 May 2012.

Postdoctoral applications should include a covering letter addressed to the Director of the collaboration, Professor Dario Alessi FRS, FRSE, detailing their reasons for applying and attaching a CV and the names and contact details of three referees.  Applicants should select up to 4 potential laboratories that they are interested to work in and those wishing to be considered for one of the positions to work on the 2-3 month rotation projects should indicate this in their covering letter highlighting any relevant experience.

Applications of PhD Studentship positions should be submitted through our studentship website ( Studentships may start any time between July 2012 to October 2013.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a Scottish Registered Charity, No. SC015096.