University of Dundee

School of Research

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‘Deciphering mixed messages: Linking ubiquitin chains to protein quality control’

Protein misfolding in the cell creates toxic species linked to an array of diseases. Therefore, protective protein quality control (PQC) mechanisms evolved to triage misfolded proteins and limit their toxic effects. Molecular chaperones recognize misfolded proteins, whereas the ubiquitin-proteasome system (UPS) promotes their clearance through the attachment of ubiquitin chains.

Scientists solve puzzle of the cellular ‘Mexican wave’

An electrifying puzzle that has evaded scientists for more than half a century, likened to a cellular Mexican wave, has finally been explained, according to a team of European scientists led by the University of Dundee. The study, published in Nature Chemistry this week, explains how the switches that control signals to and from your brain across your body, making it possible for us to move, think and feel, are controlled.