School of Research
A new preclinical candidate drug with the potential to treat visceral leishmaniasis, one of the world’s major neglected diseases, has been discovered through a close collaboration between the University of Dundee, GSK and Wellcome.
New collaborative research from the Division of Molecular Microbiology in the School has discovered that a bacterial weapon commonly used by bacteria to kill each other also attacks fungal cells. The work by Dr Sarah Coulthurst, Professor Matthias Trost in Newcastle and colleagues has been published in Nature Microbiology.
Protein misfolding in the cell creates toxic species linked to an array of diseases. Therefore, protective protein quality control (PQC) mechanisms evolved to triage misfolded proteins and limit their toxic effects. Molecular chaperones recognize misfolded proteins, whereas the ubiquitin-proteasome system (UPS) promotes their clearance through the attachment of ubiquitin chains.
An electrifying puzzle that has evaded scientists for more than half a century, likened to a cellular Mexican wave, has finally been explained, according to a team of European scientists led by the University of Dundee. The study, published in Nature Chemistry this week, explains how the switches that control signals to and from your brain across your body, making it possible for us to move, think and feel, are controlled.
A recent publication from the Näthke and Blow laboratories has been selected for a special collection of outstanding 2017/early 2018 Journal of Cell Biology articles focused on Stem Cells and Development.