University of Dundee

School of Research

Short Code: 

Dundee Rep and Wellcome Centre for Anti-Infectives Research create an exciting new collaboration for young people

An exciting new long-term collaboration has been launched between Dundee Rep Theatre and the School's Wellcome Centre for Anti-Infectives Research where together they will develop a series of innovative and diverse engagement and performance opportunities for local communities.

New class of E3 ligase discovered by Virdee lab in collaboration with van Aalten lab

Dr Virdee and colleagues in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have discovered a novel class of E3 ligase. The E3 ligase, MYCBP2, operates in a unique way, selectively transferring ubiquitin to non-lysine amino acids with selectivity for threonine. The ubiquitin is linked to the threonine amino acid via a chemically distinct ester linkage thereby uncovering an unanticipated area of cellular biology. The findings are published in Nature.

"Plants as dynamic architecture – mechanically induced plasticity from the cell to organism levels"


Biological structures are different from manmade structures in that they can grow and adapt while maintaining structural integrity. For example, bones remodel depending on the structural demands due to the exercise and weight of the animal. Plants strengthen their stems in response to physical distress, such as the increase in size and weight or being bent. A representative example is reaction wood formation, in which plants locally generate extra wood, a major load-bearing tissue, where extra structural support is needed.