School of Research
A University of Dundee researcher has uncovered why parasitic worm infections seem to protect people from developing asthma, paving the way for potential future treatments for the disease.
Although it has been known for some time that parasites called roundworms, which live in the intestines of people and animals, can prevent the development of allergic immune responses, scientists have been unable to explain how this happens.
Proteolysis-targeting chimera (PROTAC) compounds developed at the University of Dundee are being made available free of charge by the pharmaceutical company Boehringer Ingelheim through their scientific crowdsourcing platform opnMe.com. The opnMe portal provides free and open access to selected molecules for the scientific community aiming at accelerating research initiatives that can benefit patients with high unmet medical need.
Researchers within the Reagents and Services division of the MRC PPU and the MRC-University of Glasgow Centre for Virus Research (CVR) have worked extremely hard since January in order to produce expression plasmids, proteins and sheep affinity purified polyclonal antibodies to all 28 proteins encoded for by SARS-CoV-2. In addition, they have generated equivalent reagents to 10 other proteins from related Coronaviruses.
Launching today, Tuesday 12 May, the COVID-19 Protein Portal allows UK scientists to access protein reagents for critical research relating to SARS-CoV-2. Protein reagents are provided free of charge by a consortium of leading protein production laboratories, in an Open Science initiative led by Wellcome and UKRI.
Scientists and clinicians based at the Schools of Life Sciences and Medicine at the University have been awarded funding from the Chief Scientist Office that will help identify those most vulnerable to severe symptoms of coronavirus.
The team led by Professor Doreen Cantrell, a Professor of Cellular Immunology and Professor James Chalmers, a leading respiratory disease physician at Ninewells, has been awarded £294,000 to help identify patients experiencing symptoms of Covid-19 whose condition could significantly worsen.
The Universities of Glasgow and Dundee have been awarded £225,000 to rapidly screen for potential COVID-19 treatments.
The project is funded by the COVID-19 Therapeutics Accelerator, an initiative launched by the Bill & Melinda Gates Foundation, Wellcome, and Mastercard to speed up the response to the COVID-19 pandemic by funding the identification, assessment, development and scale up of treatments.
Scientists at the University of Dundee and the EMBL’s European Bioinformatics Institute (EMBL-EBI) have published online some of the largest and highest resolution images yet recorded of the SARS-CoV-2 virus, the cause of the Covid-19 pandemic.
The images were collected by a consortium of researchers from the Hubrecht Institute in Utrecht, Erasmus MC University Medical Center Rotterdam, and Maastricht University in the Netherlands.
Whole genome sequencing gives new insights into cancer genomics
- By analysing genomic data from worms, scientists detailed how mutations are caused by a combination of DNA damage and inaccurate repair
- This shows that a single DNA-damaging agent can generate a multitude of mutational signatures depending on the repair mechanisms involved in fixing the original damage
- The research could help pinpoint the causes of mutations found in the genomes of cancer patients and healthy individuals
Researchers in the School have discovered a new neurodevelopmental disease caused by genetic mutations and helped explain why patients with these mutations suffer this condition.
Around 1% of the global population are affected by intellectual disability, a condition characterised by significant limitations in both intellectual function and in adaptive behaviour. It was known that a molecule called GlcNAc was found on proteins related to intellectual disability, but its exact role in this disease remained unclear.