University of Dundee

School of Research

Short Code: 
SoR

Guarding against cancer

Researchers from the Division of Cell Signalling and Immunology in the School have shown that a drug previously used to treat Type 2 diabetes could potentially be used to protect against cancer.

A study carried out by Professors Grahame Hardie and Doreen Cantrell has shown that the drug phenformin protects mice against a type of cancer called T-cell lymphoma. It does this by switching on the protein AMPK, which was first defined by Professor Hardie in the 1980s. Subsequent research at Dundee showed a link between AMPK and cancer.

mRNA cap methylation - a key player in cancer cell growth?

One of the most prevalent cancer-causing genes or “oncogenes” is called PI3KCA.  Damaging changes or “mutations” in this oncogene are found in many cancers including cancers of the breast, colon, brain, liver, stomach and lung.   Understanding how cancer-causing genes such as PIK3CA change the behaviour of our cells is key to developing new therapies for cancer patients. 

Hannah Tovell and Ciulli lab publish optimised HaloPROTAC method

Hannah Tovell an Alessi lab PhD student working closely with the Ciulli lab has published an improved HaloPROTAC method to induce post–translational knockdown of endogenous proteins. 

This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure). 

Kate Storey wins the 2019 Waddington Medal

Professor Kate Storey has been awarded the Waddington Medal by the British Society for Developmental Biology.

The Waddington Medal is the only national award in Developmental Biology. It honours outstanding research performance as well as services to the subject community. The medal is awarded annually at the BSDB Spring Meeting, where the recipient presents the Waddington Medal Lecture.

Professor Storey is Head of the Division of Cell & Developmental Biology and Chair of Neural Development in the School of Life Sciences at Dundee.

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