University of Dundee

Molecular Medicine

Short Code: 

“Fish and Zits”

Professor Maurice van Steensel is an academic dermatologist who received his MD in 1996 from the University of Nijmegen (NL). He obtained a cum laude PhD in genetics and dermatology while training to become a dermatologist in 2005. He is currently a professor of genetic dermatology and vice-chair of the department of Dermatology in Maastricht University Medical Center, the Netherlands. He also holds a visiting professorship at the Institute of Medical Biology, A*STAR, Singapore.

Deena Leslie Pedrioli awarded MRC New Investigator Grant to support research into skin disorders

A University of Dundee scientist has been awarded a prestigious Medical Research Council New Investigator grant to pursue her work on understanding and developing treatments for skin disorders.
Dr Deena Leslie Pedrioli, of the College of Life Sciences at the University, has been awarded £450,000 by the MRC to support her work for the next three years. The grant will also create an additional research assistant post.

"Inherited cutaneous tumour syndromes: The CYLD story"

The abstract:
Rare genetic skin disease can offer new insights into common skin disease. My research group focusses on patients with germline mutations in the tumour suppressor gene CYLD, who develop disfiguring, cutaneous hair follicle tumours. Curiously, the phenotypic consequences of mutations in this lysine-63 specific ubiquitin hydrolase encoding gene are almost exclusively restricted to the skin.

"Persistence and Persisters"

Richard Titball is currently Professor of Molecular Microbiology in the Department of Biosciences at the University of Exeter. He moved to the University from the Defence Science and Technology Laboratory at Porton Down, where he was a Senior Fellow. He is also an Honorary Professor, London School of Hygiene and Tropical Medicine and a Fellow of the Royal College of Pathologists. He is a bacteriologist with a strong interest in the molecular basis of pathogenicity. This information is exploited to devise improved vaccines and antibacterial therapies for disease in humans and animals.

Irwin McLean elected Fellow of the Royal Society

Professor Irwin McLean of the University of Dundee has been elected a Fellow of the Royal Society, the world's oldest scientific academy in continuous existence.

Irwin McLean is Professor of Human Genetics, Scientific Director of the Centre for Dermatology and Genetic Medicine, and Head of the Division of Molecular Medicine at Dundee. He is a world renowned expert in the genetics of skin diseases, and his research group as identified the causative genes for more than 20 human diseases.

“Disease gene discovery: key protease functions in the epithelial barrier”

The seminar will describe our recent discoveries in genetic disorders of the skin. Specifically, I will focus on a class of proteins called proteases (enzymes that breakdown other proteins) and their inhibitors that are mutated in various skin disorders. Our cell biology investigations indicate they have key roles in cell adhesion and in the skin’s barrier and repair functions. Furthermore, these studies are also providing insight into other conditions including cardiomyopathy, bowel inflammation and cancer of the oesophagus.