University of Dundee

Molecular Medicine

Short Code: 
MM

“Evolution and pathogenesis of Staphylococcus aureus at the human-livestock interface”

Staphylococcus aureus is a major global pathogen. In addition to a wide spectrum of human diseases, S. aureus causes economically important infections of cows, sheep, poultry, and rabbits. We have been investigating the evolutionary history of S. aureus clones associated with different host species, the molecular basis for host-adaptation, and the emergence of antibiotic resistance. Using a time-scaled phylogenetic approach, we have identified ancient and recent host-switching events leading to the emergence of endemic and epidemic clones in humans and livestock.

"Finding phages to help solve the difficult problem of Clostridium difficile"

Bacteriophages play major roles in the biology of their bacterial hosts, driving bacterial pathogenicity, genome evolution and population dynamics. Additionally phages are being explored as alternatives to antibiotics for problematic infections, due to their ability to specifically lyse bacterial cells. Clostridium difficile infection (CDI) is a major healthcare problem associated with exposure to antibiotics. Part of the difficulty in combating CDI is the constant emergence of novel genotypes (ribotypes) in clinics. Outside the hospital environment, C.

Lilley Lab maps DNA repair enzyme in atomic detail

An enzyme crucial to the process of DNA repair in our cells has been mapped in atomic detail by researchers at the University of Dundee, the UK’s top-rated University for Biological Sciences.
 
DNA repair plays a key role in human diseases such as cancer. Researchers say that revealing the 3D molecular structure of a key enzyme involved in this process could be an important step towards developing future drugs.
 

Scientific Officer (in Drug Discovery)

We are seeking an experienced scientist to work as Scientific Officer on a project aimed at the development of small molecule therapeutics for human skin disease in collaboration with the Drug Discovery Unit. Applicants should have a degree in biology, chemistry, or pharmacology. You must have substantial experience in genetics, molecular biology, microbiology, tissue culture, quantitative PCR, protein biochemistry, RNA biochemistry, immunoassays, high-throughput screening and have some experience in statistical analysis.

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