University of Dundee

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

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Postdoctoral position: Functions and application of a novel stem cell signalling pathway

Greg Findlay’s lab investigates how pluripotent stem cells decide whether to self-renew or commit to differentiate towards a specific cell type or tissue. The goal of the lab is to work out underlying molecular mechanisms by which protein phosphorylation and ubiquitylation control stem cell decision-making and how these processes are disrupted to cause human developmental disorders.

UKDRI Postdoctoral Scientist in Proteomics

Summary of Job Purpose and Principal Duties

We are seeking a postdoctoral researcher with expertise in the latest cutting-edge mass spectrometry techniques and a keen interest in neurodegenerative disease research to undertake collaborative studies with groups based within the UK Dementia Research Institute (UK DRI – The UK DRI brings together expertise from six leading UK universities to research the key questions in neurodegenerative disease and accelerate the development of treatments.

EASTBIO: Regulation of mRNA capping in embryonic stem cells

Embryonic stem cells are pluripotent cells derived from early embryos that retain the ability to differentiate into all somatic cells.  Pluripotency is dependent on the expression of key pluripotency regulators.  On receiving signals to differentiate, gene expression profiles are reshaped to repress pluripotency factors and to express the proteins required of the new cell lineage.  Our focus is on understanding how cellular signalling pathways regulate the mRNA cap, a structure added to transcripts which is critical for gene expression.   The student will investigate how cellular signalling

Postdoctoral Researcher

Summary of Job Purpose and Principal Duties:

Post-doctoral position: Characterisation of physiological substrates of the NEK1 kinase complex and the functional impact of disease-causing mutations

The Rouse lab is interested in how cells sense, signal and repair damaged DNA, and how they cope with DNA damage. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation.