University of Dundee

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

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Postdoctoral Research Assistants (DNA repair mechanisms and human disease)

The Rouse lab is interested in how cells sense, signal and repair damaged DNA, and how they cope when DNA damage – or other obstacles – blocks the process of DNA replication. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Disrupting DNA repair causes human disease, and yet inhibiting DNA repair pathways acutely is an important way of destroying tumours.

“Stress-mediated regulation of proteasome homeostasis”.

Accumulation of unfolded, misfolded, or damaged proteins is deleterious to cells. To avoid such potentially harmful conditions, cells have evolved efficient protein quality control systems (PQC). One of the key effectors of this PQC is the ubiquitin–proteasome system. In this system, ubiquitin-tagged proteins are recognized by the 26S proteasome for proteolytic destruction.