University of Dundee

Drug Discovery Unit

Short Code: 
DDU

International collaboration provides new insights into the fight against African sleeping sickness

The African trypanosome causes African sleeping sickness, a hideous disease transmitted by the tsetse fly that, untreated, leads to character disintegration, comma and death. The trypanosome parasite evades the patient’s immune system by ‘antigenic variation’, which is the swapping one protective surface coat for another. 

Professor Victoria Cowling receives Royal Society Wolfson Research Merit Award

Professor Victoria Cowling was selected by UK Research and Innovation (UKRI) as one of their case studies for the launch last week of their new prestigious £900 million Future Leaders Fellowship Scheme. In 2007, she was a recipient of UK government funding through a Medical Research Council (MRC) Career Development Award. This initial investment in Vicky to allowed her to study a cancer-causing protein called Myc.

New Proteomic Study of Trypanosome Cell Cycle

A new study entitled “Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei” has just been published in Molecular and Cellular Proteomics (Crozier et al., 2018, Mol Cell Proteomics 2018 17: 1184-1195). This study resulted from a collaboration between the laboratories of Mike Ferguson (BCDD) and Angus Lamond (GRE).  Trypanosoma brucei is an evolutionarily divergent eukaryotic protozoan parasite that causes human and animal trypanosomiasis (also called ‘sleeping sickness’) in sub-Saharan Africa.

DNDi, GlaxoSmithKline, and University of Dundee to identify drug candidates to treat leishmaniasis and Chagas disease

The Drug Discovery Unit (DDU) will collaborate with the not-for-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) and GlaxoSmithKline (GSK) in a bid to discover new pre-clinical drug candidates targeting two parasitic neglected tropical diseases (NTDs), leishmaniasis and Chagas disease.

Congratulations following Promotions for Academic Staff

Kevin Read and Simon Arthur have been promoted to Personal Chair (Professor) as part of the 2017 Annual Review process for academic staff. Kevin Read will become Professor of Quantitative Pharmacology while Simon Arthur will be Professor of Immune Signalling.

“I would like to congratulate both Kevin and Simon on their well-deserved promotions,” said Professor Julian Blow, Dean of Research in the School of Life Sciences. “Both have made significant contributions to their respective fields over a sustained period of time as well as contributing to teaching our undergraduates.”

Biotransformation Expert

We are seeking a personable and enthusiastic individual to take up the post of Biotransformation Expert within the Drug Metabolism and Pharmacokinetics (DMPK) team in the Drug Discovery Unit (DDU), University of Dundee. The DDU has a strong focus to find new drugs to treat diseases of the developing world such as malaria, tuberculosis, visceral leishmaniasis and Chagas disease (see www.drugdiscovery.dundee.ac.uk).

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