Drug Discovery Unit
Prof Paul Wyatt. Head of the Drug Discovery Unit, and Director of the Wellcome Centre for Anti-Infectives Research, University of Dundee is seeking a highly motivated and enthusiastic synthetic organic or medicinal chemist to carry out a PhD focused on developing innovative chemistry methodology to efficiently synthesise novel heterocycles as fragments. Fragments are low molecular weight and low complexity organic molecules suitable for initiating drug discovery projects.
Researchers at the University of Dundee have identified a new drug target in parasites that cause major neglected tropical diseases, a discovery that contributes towards a global drive to eliminate these diseases by 2030.
A new preclinical candidate drug with the potential to treat visceral leishmaniasis, one of the world’s major neglected diseases, has been discovered through a close collaboration between the University of Dundee, GSK and Wellcome.
The African trypanosome causes African sleeping sickness, a hideous disease transmitted by the tsetse fly that, untreated, leads to character disintegration, comma and death. The trypanosome parasite evades the patient’s immune system by ‘antigenic variation’, which is the swapping one protective surface coat for another.
Professor Victoria Cowling was selected by UK Research and Innovation (UKRI) as one of their case studies for the launch last week of their new prestigious £900 million Future Leaders Fellowship Scheme. In 2007, she was a recipient of UK government funding through a Medical Research Council (MRC) Career Development Award. This initial investment in Vicky to allowed her to study a cancer-causing protein called Myc.
A new study entitled “Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei” has just been published in Molecular and Cellular Proteomics (Crozier et al., 2018, Mol Cell Proteomics 2018 17: 1184-1195). This study resulted from a collaboration between the laboratories of Mike Ferguson (BCDD) and Angus Lamond (GRE). Trypanosoma brucei is an evolutionarily divergent eukaryotic protozoan parasite that causes human and animal trypanosomiasis (also called ‘sleeping sickness’) in sub-Saharan Africa.
The University of Dundee’s contribution to the UK’s strength in the global life sciences sector is being highlighted this week by its Drug Discovery Unit at one of the world’s major scientific gatherings, the 2018 BIO International Convention in Boston.
Scientists from the University of Dundee will swap lab coats for hiking boots this weekend as they take on one of Scotland’s greatest wildlife trails for charity.
A team of four scientists from the University’s School of Life Sciences, hope to finish the 52 mile Cateran Trail within just five days as they aim to raise funds for Cats Protection and Re-Act Scotland.
The Drug Discovery Unit (DDU) is a fully integrated, operational drug discovery group established in 2006 at the University of Dundee to translate world-class biology research into novel drug targets and candidate drugs across a range of therapeutic areas.