University of Dundee

Drug Discovery Unit

Short Code: 
DDU

Developing innovative chemistry methodology to efficiently synthesise novel heterocycles as fragments.

Prof Paul Wyatt. Head of the Drug Discovery Unit, and Director of the Wellcome Centre for Anti-Infectives Research, University of Dundee is seeking a highly motivated and enthusiastic synthetic organic or medicinal chemist to carry out a PhD focused on developing innovative chemistry methodology to efficiently synthesise novel heterocycles as fragments. Fragments are low molecular weight and low complexity organic molecules suitable for initiating drug discovery projects.

International collaboration provides new insights into the fight against African sleeping sickness

The African trypanosome causes African sleeping sickness, a hideous disease transmitted by the tsetse fly that, untreated, leads to character disintegration, comma and death. The trypanosome parasite evades the patient’s immune system by ‘antigenic variation’, which is the swapping one protective surface coat for another. 

Professor Victoria Cowling receives Royal Society Wolfson Research Merit Award

Professor Victoria Cowling was selected by UK Research and Innovation (UKRI) as one of their case studies for the launch last week of their new prestigious £900 million Future Leaders Fellowship Scheme. In 2007, she was a recipient of UK government funding through a Medical Research Council (MRC) Career Development Award. This initial investment in Vicky to allowed her to study a cancer-causing protein called Myc.

New Proteomic Study of Trypanosome Cell Cycle

A new study entitled “Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei” has just been published in Molecular and Cellular Proteomics (Crozier et al., 2018, Mol Cell Proteomics 2018 17: 1184-1195). This study resulted from a collaboration between the laboratories of Mike Ferguson (BCDD) and Angus Lamond (GRE).  Trypanosoma brucei is an evolutionarily divergent eukaryotic protozoan parasite that causes human and animal trypanosomiasis (also called ‘sleeping sickness’) in sub-Saharan Africa.

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