One of the most prevalent cancer-causing genes or “oncogenes” is called PI3KCA. Damaging changes or “mutations” in this oncogene are found in many cancers including cancers of the breast, colon, brain, liver, stomach and lung. Understanding how cancer-causing genes such as PIK3CA change the behaviour of our cells is key to developing new therapies for cancer patients.
Centre for Gene Regulation and Expression
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
Applications are invited for one or more Principal Investigator (PI) positions from candidates wishing to establish a research group working on any aspect of nuclear function, joining the Centre for Gene Regulation and Expression in Dundee.
The Centre for Gene Regulation and Expression comprises 14 research groups. These groups include over one hundred postdoctoral and postgraduate scientists studying gene expression and genome integrity often making use of excellent core facilities in areas such as imaging, proteomics, genomics stem cell culture and drug discovery.
Following the destruction of lab space by the fire at Biomedical Sciences Building at the University of St Andrews, 8 researchers from the groups of David Hughes and Rick Randall will be accommodated within Gene Regulation and Expression in the School.
Abstract to be confirmed.
In a new study, researchers from the University of Copenhagen and EMBL in Heidelberg have learned how a specific genetic mutation affects the maturation of blood cells in mouse models. Leukaemia patients often have a mutation in this gene, often seen before the disease sets in. The researchers are working on a strategy for treating the mutation.
Research Technician position to support biochemistry work as part of a large program to develop new antifungal compounds in the laboratory of Professor Daan van Aalten FRSE.