University of Dundee

Centre for Gene Regulation and Expression

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Postdoctoral Research Assistant

Applications are invited for an ERC funded postdoctoral position in the Alabert Lab to study the fundamentals of chromatin replication and cell identity. During lineage propagation, cells must duplicate their genetic and epigenetic information to maintain cell identity. The mechanisms underlying the duplication of epigenetic information in cycling cells remains largely unknown. Recently we have developed a new technology to analyse this process in vivo (see Alabert et al., NCB 2014 Mar;16(3):281-93 and Alabert et al., G&D 2015 Mar 15;29(6):585-90).

4 Year MRC PhD Programme: Single particle cryo-electron microscopy and molecular modelling of chromatin remodelling complexes

The genomes of eukaryotes exist as chromatin. The way that chromatin is organised is used as a means of regulating access to the underlying genetic information. Altering the conformation is achieved through the co-ordinated action of a series of different types of alteration to chromatin. These include, DNA methylation, post-translational modification of histones and association with a variety of nucleosome binding proteins.

Postdoctoral Research Assistant

The laboratory of Dr. Federico Pelisch is seeking a highly motivated postdoctoral applicant to study how the Small Ubiquitin-related Modifier (SUMO) regulates protein complexes during cell division. Specifically, the project focuses on the cross-talk between SUMOylation and phosphorylation during meiosis, with an emphasis on understanding how the balance between SUMO E3 ligases and proteases as well as kinases and phosphatases is achieved in vivo. The project will use mainly the nematode C. elegans as a model, but mammalian systems will also be used.

Investigating mRNA cap regulation in ES cells and T cells

We investigate the regulation and function of the mRNA cap, a modification of RNA essential for gene expression which integrates transcript processing and translation.  We are beginning to understand how oncogenes and signalling pathways can regulate gene expression via regulation of mRNA capping enzymes. Signalling pathways which modify the mRNA capping enzymes have the potential to change the gene expression landscape, thus causing changes in cell physiology.