Cell Signalling and Immunology
A scientific collaboration between researchers in Scotland and China has uncovered a new kind of `energy sensor’ in our cells, changing our understanding of how the body monitors glucose levels and switches on the supply of alternative `fuels’.
It is thought the research, published in the journal Nature, could have particular implications for diabetes, in which the level of glucose in the blood is abnormally high.
We are seeking an enthusiastic and motivated research technician to join the newly established laboratory of Dr. David McEwan at the University of Dundee to support an exciting project to study the role of immune cells in combating infection. The successful applicant will work as part of a multidisciplinary team interested in understanding immune cell regulation. In particular, we have a primary focus on the process of autophagy (meaning “Self-eating”) that is utilized by cells to destroy intracellular pathogens, remove damaged organelles and proteins aggregates.
Former Dundee researcher, Dr David Finlay, publishes recent findings in leading international journal Nature Communications. The work involved input from Dr Linda Sinclair from Professor Doreen Cantrell’s laboratory in the School who have a continuing collaboration with the Finlay group.
Glucose – commonly referred to as a ‘simple’ sugar – may be a crucial factor in the fight against cancer and inflammatory disease after scientists discovered a new role for glucose in the stimulation of cells that work on the front line in the fight against infection and tumours.
The Phenomics Discovery Initiative (PDi), a unique collaboration between the pharmaceutical industry and academia, has unveiled its first series of novel phenotypic assays. The assays are under development within the labs of the National Phenotypic Screening Centre (NPSC) – a collaboration between the Universities of Dundee, Edinburgh and Oxford - and are designed to identify new molecules with pharmacological activity in respiratory, oncology, immunology and c
Alan Prescott has been award 3rd Prize in the British Society of Cell Biology (BSCB) Image Competition 2017. His confocal image is of a transverse section of the rectus muscle of the eye taken from the mito-QC mouse (McWilliams et al., (2016) JCB, 214(3)). Mitochondria express eGFP and mCherry but in lysosomes the eGFP, green fluorescence is quenched. Bright red dots are mitolysosomes. Nuclei are DAPI blue.
School of Life Sciences scientists have won a hat-trick of funding awards from the Wellcome Trust that will see more than £6million invested in their research. Professors Doreen Cantrell, Mark Field and Grahame Hardie have been successful in winning grants from Wellcome.