New research has deciphered how rogue communications in blood stem cells can cause Leukaemia. The discovery, published in the journal Science, could pave the way for new, targeted medical treatments that block this process. Blood cancers like leukaemia occur when mutations in stem cells cause them to produce too many blood cells.
Cell Signalling and Immunology
University of Dundee researchers have shown how a natural product derived from a group of fungi that has inspired horror novels, movies and computer games works to switch on a protein known to affect cancer cells.
Dr. Henry McSorley has joined the School this month as a member of the Division on Cell Signalling and Immunology. He will be joint deputy head of division alongside Hari Hundal.
Researchers in the Moraga group report the engineering of new tools to manipulate the immune response with the potential to treat human disorders. The research was done in collaboration with the Kazemian group (Purdue University, USA) and Mitra group (Centre de Recherche Jean-Pierre Aubert, France). The research was published in the journal eLife.
Species from several fungal genera, including Candida, Aspergillus, Pneumocystis and Cryptococuss have the potential to give rise to serious clinical infections and are estimated to cause 1.5 million deaths per year. Despite their importance as human pathogens, our understanding of how they affect immune cells, and how this might be affected by the presence of other pathogens is incomplete.
The School has welcomed three new group leaders in recent months. They are currently establishing their laboratories across three of our divisions. Leeanne McGurk has joined the Division of Cell and Developmental Biology, Megan Bergkessel has joined the Division of Molecular Microbiology while Gabriel Sollberger has joined the Division of Cell Signalling and Immunology.
Leeanne joins the School from the University of Pennsylvania, Philadelphia where she was a postdoctoral research associate in the laboratory of Nancy Bonini.