University of Dundee

Cell and Developmental Biology

Short Code: 
CDB

China Scholarship Council PhD Programme: Structural and membrane biology of polarized trafficking

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. We aim to understand the role of protein complexes including the exocyst. This project seeks to answer mechanistic questions regarding 1) the regulation of protein structural mechanics in polarized trafficking, 2) and the consequences of signaling on this pathway and its organization.

Postdoctoral Research Assistant

Postdoctoral position in the development and applications of advanced Lightsheet Microscopy in Life Sciences

We are seeking an outstanding researcher at PhD or equivalent level of experience possessing a high level of technical skill and expertise in the design and implementation of advanced fluorescence microscopes and their applications in biomedical research.

MRC DTP 4 Year PhD Programme: Structural and developmental mechanics in polarized membrane trafficking

Membranes and their protein organization are a frontier in our understanding of cell biology. We will focus on polarized trafficking and asymmetric cell division as a model to uncover fundamental mechanisms in biology. This project aims to answer mechanistic questions in 1) the regulation of protein structural mechanics in polarized trafficking, 2) and the consequences and fundamental differences in this pathway’s organization between distinct tissues in development. Our philosophy is to address big-picture questions of challenging biology in a hypothesis-driven research project.

4 Year Wellcome Trust Programme: Regulation and mechanics in polarity

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. We aim to understand the role of protein complexes including the exocyst. This project seeks to answer mechanistic questions regarding 1) the regulation of protein structural mechanics in polarized trafficking, 2) and the consequences of signalling on this pathway and its organization.

4 Year Wellcome Trust PhD Programme: Mechanisms of asymmetric stem cell division

Despite tremendous progress the origin of cancer is still a matter of debate for many malignancies, but it is clear that stem cells play an important part in this context. How are stem cells and the onset of tumorigenesis linked? Some stem cells can divide asymmetrically. This means that when they divide the stem cells self-renew and at the same time produce a daughter cell that will have another fate. If this process of cell fate assignment by asymmetric stem cell division goes wrong, tumourigenesis can be triggered.

4 Year Wellcome Trust PhD Programme: Role of NICD stability turnover in development and breast cancer.

My lab has recently found Notch ICD stability is regulated in a cell cycle dependent manner. We have shown this in HEK293 cells. This work is currently under revision. We want to move this into the embryo and into a translational context. In the embryo we wish to see how this links Notch function in cell differentiation with cell proliferation in the variety of tissue contexts where Notch plays a role.

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