University of Dundee

Biological Chemistry and Drug Discovery

Short Code: 
BCDD

Computational Chemistry/Machine Learning/AI Scientist

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Chemoinformatics/Computational Chemistry Scientist

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Postdoctoral Research Assistant – Cancer Cell Biology of Targeted Protein Degradation

Professor Alessio Ciulli’s laboratory is seeking a postdoctoral researcher to undertake research in collaboration with the pharmaceutical company Eisai Co. Ltd. The project will apply novel cell biology and biochemical approaches to investigate mechanisms of targeted protein degradation and of novel degrader molecules to treat cancers and elucidate their mechanism of action.

PROTACs go macrocyclic

Researchers in the Ciulli group report a first study describing the idea of a macrocyclic PROTAC. The research was published in the prestigious chemistry journal Angewandte Chemie.

PROTACs (for proteolysis-targeting chimeras) are double-headed molecules composed of a ligand for a target protein and a ligand for an E3 ubiquitin ligase, chemically joined by a flexible linker. The PROTAC simultaneously recruits the target protein and the E3 ligase into close proximity, and this leads to the target protein being destroyed inside the cell.

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