University of Dundee

Biological Chemistry and Drug Discovery

Short Code: 
BCDD

Hannah Tovell and Ciulli lab publish optimised HaloPROTAC method

Hannah Tovell an Alessi lab PhD student working closely with the Ciulli lab has published an improved HaloPROTAC method to induce post–translational knockdown of endogenous proteins. 

This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure). 

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