University of Dundee

Biological Chemistry and Drug Discovery

Short Code: 
BCDD

University of Dundee and Boehringer Ingelheim collaboration releases further free access PROTAC compounds on opnMe.com

Proteolysis-targeting chimera (PROTAC) compounds developed at the University of Dundee are being made available free of charge by the pharmaceutical company Boehringer Ingelheim through their scientific crowdsourcing platform opnMe.com. The opnMe portal provides free and open access to selected molecules for the scientific community aiming at accelerating research initiatives that can benefit patients with high unmet medical need.

Postdoctoral Research Assistant (Organic Medicinal Chemistry / Chemical Biology)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Structural Biology / Biophysics Scientists (PROTAC drug discovery)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Dundee part of expanding international research effort against COVID-19

The University of Dundee is working with partners around the world as part of an expanding effort to rapidly repurpose existing drugs against Covid-19.

An international research network established by Scripps Research centres around ReFRAME, the world’s leading collection of drugs known to be safe in humans.

The network of collaborating scientific laboratories is aiming to leverage ReFRAME to find antiviral compounds against the novel coronavirus.

MRC DTP iCASE PhD Project: Developing novel biophysical and cellular assays to study small-molecule mediated protein ubiquitination and degradation

Bifunctional degrader molecules also known as Proteolysis Targeting Chimeras (PROTACs) and the mechanistically related monovalent degraders (for example auxin, lenalidomide and indisulam) work by co-opting an E3 ubiquitin ligase to act upon a neo-substrate protein. Formation of a ternary complex species between the E3 ligase, the degrader molecule and the target protein leads to the latter being ubiquitinated and subsequently degraded by the proteasome.

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