University of Dundee

MRC Protein Phosphorylation Unit 2018

Alessi DR, Sammler E. 2018. LRRK2 kinase in Parkinson's disease. Science. 360(6384):36-37. Available from: 10.1126/science.aar5683

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK. 2018. The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1. ChemBioChem. 19(5):425-429. Available from: 10.1002/cbic.201700500

Bozatzi P, Dingwell KS, Wu KZL, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP. 2018. PAWS1 controls Wnt signalling through association with casein kinase 1α. EMBO Reports. 19(4):1-18. Available from: 10.15252/embr.201744807

Bozatzi P, Sapkota G. 2018. The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms. Biochemical Society Transactions. 2018:1-11. Available from: 10.1042/BST20160277

Bustos F, Segarra Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay R, Walden H, Findlay G. 2018. RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation. Cell Reports. 23:1599-1611. Available from: 10.1016/j.celrep.2018.04.022

Cohen P. 2018. Ubiquitin chains as second messengers. Nature Reviews Molecular Cell Biology. 19. Available from: 10.1038/nrm.2018.9

Cummins TD, Wu KZL, Bozatzi P, Dingwell KS, Macartney TJ, Wood NT, Varghese J, Gourlay R, Campbell DG, Prescott A, Griffis E, Smith JC, Sapkota GP. 2018. PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP. Journal of Cell Science. 131(1):1-12. Available from: Final published version10.1242/jcs.202390

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan A, Lanz TA, Kofler JK, Burton EA, Alessi D, Hastings TG, Greenamyre JT. 2018. A Central Role for LRRK2 in Idiopathic Parkinson Disease. Science Translational Medicine.

Fan Y, Howden AJM, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler E. 2018. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. Biochemical Journal. 475(1):23-44. Available from: 10.1042/BCJ20170803

Fulcher L, Bozatzi P, Tachie-Menson T, Wu K, Cummins TD, Bufton JC, Pinkas DM, Dunbar K, Shrestha S, Wood N, Weidlich S, Macartney T, Varghese J, Gourlay R, Campbell D, Dingwell KS, Smith JC, Bullock AN, Sapkota G. 2018. The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. Science Signaling. 11(531). Available from: 10.1126/scisignal.aao2341

Graciela Cervantes-Perez L, Castaneda-Bueno M, Jimenez JV, Vazquez N, Rojas-Vega L, Alessi D, Bobadilla NA, Gamba G. 2018. Disruption of the with no lysine kinase^STE20-proline alanine-rich kinase pathway reduces thehypertension induced by angiotensin II. Journal of Hypertension. 36(2):361-367. Available from: 10.1097/HJH.0000000000001554

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG. 2018. LRRK2 is a negative regulator of phagosome maturation in macrophages. The EMBO Journal. 2018:1-17. Available from: 10.15252/embj.201798694

Hong Y, Sonneville R, Wang B, Scheidt V, Meier B, Woglar A, Demetriou S, Labib K, Jantsch V, Gartner A. 2018. LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nature Communications. 9:1-11. Available from: 10.1038/s41467-018-03135-w

Hong Y, Velkova M, Silva N, Jagut M, Scheidt V, Labib K, Jantsch V, Gartner A. 2018. The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans. PLoS Genetics. 14(6):1-22. Available from: 10.1371/journal.pgen.1007453

Jowsey P, Morrice NA, Hastie CJ, MacLauchlan H, Toth R, Rouse J. 2018. Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544]. DNA Repair. 65:80. Available from: 10.1016/j.dnarep.2017.10.012

Kwasna D, Rehman SAA, Natarajan J, Matthews S, Madden R, De Cesare V, Weidlich S, Virdee S, Ahel I, Gibbs-Seymour I, Kulathu Y. 2018. Discovery and characterization of ZUFSP/ZUP1, a distinct DUB class important for genome stability. Molecular Cell. 70:1-15. Available from: 10.1016/j.molcel.2018.02.023

Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Rehman SAA, Pathak D, Weidlich S, Zoephel A, Bordone MC, Barbosa-Morais NL, Boehmelt G, Kulathu Y. 2018. Expansion of DUB functionality by alternative isoforms: USP35, a case study . Journal of Cell Science. 131. Available from: 10.1242/jcs.212753

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Winglok Ho P, Ho S-L, Chou M-Y, Polinski NK, Martinez TN, Davies P, Alessi DR. 2018. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase. Biochemical Journal. 475(1):1-22. Available from: 10.1042/BCJ20170802

Malik N, Macartney T, Hornberger A, Anderson K, Tovell H, Prescott AR, Alessi DR. 2018. Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks. Biochemical Journal. 475(1):117-135. Available from: 10.1042/BCJ20170650

McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG. 2018. Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand. Cell Metabolism. 27(2):439-449.e5. Available from: 10.1016/j.cmet.2017.12.008

Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou M-Y, Howden A, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi D. 2018. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human. Biochemical Journal. 475(11):1861-1883. Available from: 10.1042/BCJ20180248

Pao K-C, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S. 2018. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Nature. 556:381-385. Available from: 10.1038/s41586-018-0026-1

Ramachandran A, Vizan P, Das D, Chakravarty P, Vogt J, Rogers KW, Müller P, Hinck AP, Sapkota GP, Hill CS. 2018. TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition. eLife. 7:1-29. Available from: 10.7554/eLife.31756

Thomas Y, Scott DC, Kristariyanto YA, Rinehart J, Clark K, Cohen P, Kurz T. 2018. The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. PLoS ONE. 13(6):1-19. Available from: 10.1371/journal.pone.0199197

Wan X, Serrill JD, Humphreys IR, Tan M, McPhail KL, Ganley IG, Ishmael JE. 2018. ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A. Marine Drugs. 16(3):1-20. Available from: 10.3390/md16030077