Bakshi, S., Taylor, J., Strickson, S., McCartney, T. and Cohen, P. (2017) Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon beta. Biochem. J. 474, 1163-1174
doi. 10.1042/BCJ20160992, 2017
PMID 28159912
PMC 5350611
Cohen, P. and Strickson, S. (2017) The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways. Cell Death Differ. 24, 1153-1159
doi. 10.1038/cdd.2017.17, 2017
PMID 28475177
PMC 5520163
Cummins, T. D. and Sapkota, G. P. (2017) Characterization of Protein Complexes Using Chemical Cross-Linking Coupled Electrospray Mass Spectrometry. Methods Mol. Biol.,
doi. 10.1007/7651_2017_85, 2017
PMID 29064006
Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. and Sapkota, G. P. (2018) PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP. J. Cell Sci. 131,
doi. 10.1242/jcs.202390, 2018
PMID 29175910
Darling, N. J., Toth, R., Arthur, J. S. and Clark, K. (2017) Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. Biochem. J. 474, 521-537
doi. 10.1042/BCJ20160646, 2017
PMID 27920213
PMC 5290485
Feeney, L., Munoz, I. M., Lachaud, C., Toth, R., Appleton, P. L., Schindler, D. and Rouse, J. (2017) RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health. Mol. Cell. 66, 610-621 e614
doi. 10.1016/j.molcel.2017.04.021, 2017
PMID 28575657
PMC 5459755
Fernandez-Alonso, R., Bustos, F., Williams, C. A. C. and Findlay, G. M. (2017) Protein Kinases in Pluripotency-Beyond the Usual Suspects. J. Mol. Biol. 429, 1504-1520
doi. 10.1016/j.jmb.2017.04.013, 2017
PMID 28456524
Fernandez-Alonso, R., Davidson, L., Hukelmann, J., Zengerle, M., Prescott, A. R., Lamond, A., Ciulli, A., Sapkota, G. P. and Findlay, G. M. (2017) Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification. EMBO reports. 18, 1108-1122
doi. 10.15252/embr.201643534, 2017
PMID 28588073 PMC 5494510
Findlay, G. M., David, L. and Beyer, T. A. (2017) Molecular Mechanisms of Stem Cell Pluripotency and Cell Fate Specification. J. Mol. Biol. 429, 1439-1440
doi. 10.1016/j.jmb.2017.03.011, 2017
PMID 28302388
Fulcher, L. J., Hutchinson, L. D., Macartney, T. J., Turnbull, C. and Sapkota, G. P. (2017) Targeting endogenous proteins for degradation through the affinity-directed protein missile system. Open Biol. 7,
doi. 10.1098/rsob.170066, 2017
PMID 28490657
PMC 5451546
Hall, E. A., Nahorski, M. S., Murray, L. M., Shaheen, R., Perkins, E., Dissanayake, K. N., Kristaryanto, Y., Jones, R. A., Vogt, J., Rivagorda, M., Handley, M. T., Mali, G. R., Quidwai, T., Soares, D. C., Keighren, M. A., McKie, L., Mort, R. L., Gammoh, N., Garcia-Munoz, A., Davey, T., Vermeren, M., Walsh, D., Budd, P., Aligianis, I. A., Faqeih, E., Quigley, A. J., Jackson, I. J., Kulathu, Y., Jackson, M., Ribchester, R. R., von Kriegsheim, A., Alkuraya, F. S., Woods, C. G., Maher, E. R. and Mill, P. (2017) PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Am. J. Hum. Genet. 100, 706-724
doi. 10.1016/j.ajhg.2017.03.008, 2017
PMID 28413018
PMC 5420347
Hardie, D. G. (2017) An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation. Cancer Cell. 31, 163-165
doi. 10.1016/j.ccell.2017.01.010, 2017
PMID 28196589
Hartlova, A., Peltier, J., Bilkei-Gorzo, O. and Trost, M. (2017) Isolation and Western Blotting of Latex-Bead Phagosomes to Track Phagosome Maturation. Methods Mol. Biol. 1519, 241-248
doi. 10.1007/978-1-4939-6581-6_16, 2017
PMID 27815884
Hatcher, J. M., Choi, H. G., Alessi, D. R. and Gray, N. S. (2017) Small-Molecule Inhibitors of LRRK2. Adv Neurobiol. 14, 241-264
doi. 10.1007/978-3-319-49969-7_13, 2017
PMID 28353288
Jayachandran, N., Landego, I., Hou, S., Alessi, D. R. and Marshall, A. J. (2017) B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. Eur. J. Immunol. 47, 280-290
doi. 10.1002/eji.201646596, 2017
PMID 27859053
Kategaya, L., Di Lello, P., Rouge, L., Pastor, R., Clark, K. R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J. P., Prakash, S., Heideker, J., McCleland, M., Ritorto, M. S., Alessi, D. R., Trost, M., Bainbridge, T. W., Kwok, M. C. M., Ma, T. P., Stiffler, Z., Brasher, B., Tang, Y., Jaishankar, P., Hearn, B. R., Renslo, A. R., Arkin, M. R., Cohen, F., Yu, K., Peale, F., Gnad, F., Chang, M. T., Klijn, C., Blackwood, E., Martin, S. E., Forrest, W. F., Ernst, J. A., Ndubaku, C., Wang, X., Beresini, M. H., Tsui, V., Schwerdtfeger, C., Blake, R. A., Murray, J., Maurer, T. and Wertz, I. E. (2017) USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 550, 534-538
doi. 10.1038/nature24006, 2017
PMID 29045385
Kristariyanto, Y. A., Abdul Rehman, S. A., Weidlich, S., Knebel, A. and Kulathu, Y. (2017) A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. EMBO reports. 18, 392-402
doi. 10.15252/embr.201643205, 2017
PMID 28082312
PMC 5331195
Kumar, A., Chaugule, V. K., Condos, T. E. C., Barber, K. R., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Shaw, G. S. and Walden, H. (2017) Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity. Nat. Struct. Mol. Biol. 24, 475-483
doi. 10.1038/nsmb.3400, 2017
PMID 28414322
PMC 5420311
Kumar, A., Tamjar, J., Waddell, A. D., Woodroof, H. I., Raimi, O. G., Shaw, A. M., Peggie, M., Muqit, M. M. and van Aalten, D. M. (2017) Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations. Elife. 6,
doi. 10.7554/eLife.29985, 2017
PMID 28980524
PMC 5679756
Leznicki, P. and Kulathu, Y. (2017) Mechanisms of regulation and diversification of deubiquitylating enzyme function. J. Cell Sci. 130, 1997-2006
doi. 10.1242/jcs.201855, 2017
PMID 28476940
Lopez-Guerrero, A. M., Tomas-Martin, P., Pascual-Caro, C., Macartney, T., Rojas-Fernandez, A., Ball, G., Alessi, D. R., Pozo-Guisado, E. and Martin-Romero, F. J. (2017) Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains. Sci. Rep. 7, 383
doi. 10.1038/s41598-017-00331-4, 2017
PMID 28341841
PMC 5428229
Magiera, K., Tomala, M., Kubica, K., De Cesare, V., Trost, M., Zieba, B. J., Kachamakova-Trojanowska, N., Les, M., Dubin, G., Holak, T. A. and Skalniak, L. (2017) Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell chemical biology. 24, 458-470 e418
doi. 10.1016/j.chembiol.2017.03.002, 2017
PMID 28343940
PMC 5404848
Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. and Ciulli, A. (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 8, 830
doi. 10.1038/s41467-017-00954-1, 2017
PMID 29018234
PMC 5635026
Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. and Labib, K. (2017) Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep. 18, 3033-3042
doi. 10.1016/j.celrep.2017.03.020, 2017
PMID 28355556
PMC 5382235
Morreale, F. E., Bortoluzzi, A., Chaugule, V. K., Arkinson, C., Walden, H. and Ciulli, A. (2017) Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. J. Med. Chem. 60, 4093-4098
doi. 10.1021/acs.jmedchem.7b00147, 2017
PMID 28437106
PMC 5441753
Osgerby, L., Lai, Y. C., Thornton, P. J., Amalfitano, J., Le Duff, C. S., Jabeen, I., Kadri, H., Miccoli, A., Tucker, J. H. R., Muqit, M. M. K. and Mehellou, Y. (2017) Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization. J. Med. Chem. 60, 3518-3524
doi. 10.1021/acs.jmedchem.6b01897, 2017
PMID 28323427
PMC 5410652
Pauwels, A. M., Trost, M., Beyaert, R. and Hoffmann, E. (2017) Patterns, Receptors, and Signals: Regulation of Phagosome Maturation. Trends Immunol. 38, 407-422
doi. 10.1016/j.it.2017.03.006, 2017
PMID 28416446
PMC 5455985
Peltier, J., Hartlova, A. and Trost, M. (2017) Assessing the Phagosome Proteome by Quantitative Mass Spectrometry. Methods Mol. Biol. 1519, 249-263
doi. 10.1007/978-1-4939-6581-6_17, 2017
PMID 27815885
Rena, G., Hardie, D. G. and Pearson, E. R. (2017) The mechanisms of action of metformin. Diabetologia. 60, 1577-1585
doi. 10.1007/s00125-017-4342-z, 2017
PMID 28776086
PMC 5552828
Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. and Hardie, D. G. (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell chemical biology. 24, 813-824 e814
doi. 10.1016/j.chembiol.2017.05.021, 2017
PMID 28625738
PMC 5522529
Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. and van Aalten, D. M. F. (2017) A mutant O-GlcNAcase enriches Drosophila developmental regulators. Nat. Chem. Biol. 13, 882-887
doi. 10.1038/nchembio.2404, 2017
PMID 28604694
Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D. H., Delpire, E. and Kahle, K. T. (2017) WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell metabolism. 25, 285-299
doi. 10.1016/j.cmet.2017.01.007, 2017
PMID 28178566
Sonneville, R., Moreno, S. P., Knebel, A., Johnson, C., Hastie, C. J., Gartner, A., Gambus, A. and Labib, K. (2017) CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Nat. Cell Biol. 19, 468-479
doi. 10.1038/ncb3500, 2017
PMID 28368371
PMC 5410169
Strickson, S., Emmerich, C. H., Goh, E. T. H., Zhang, J., Kelsall, I. R., Macartney, T., Hastie, C. J., Knebel, A., Peggie, M., Marchesi, F., Arthur, J. S. C. and Cohen, P. (2017) Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc. Natl. Acad. Sci. U. S. A. 114, E3481-E3489
doi. 10.1073/pnas.1702367114, 2017
PMID 28404732
PMC 5410814
Virdee, S. (2017) 2016 EMBO Chemical Biology Conference. ChemBioChem. 18, 66-71
doi. 10.1002/cbic.201600597, 2017
PMID 27862792
Vollmer, S., Strickson, S., Zhang, T., Gray, N., Lee, K. L., Rao, V. R. and Cohen, P. (2017) The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists. Biochem. J. 474, 2027-2038
doi. 10.1042/BCJ20170097, 2017
PMID 28512203
PMC 5460469
Walden, H. and Muqit, M. M. (2017) Ubiquitin and Parkinson's disease through the looking glass of genetics. Biochem. J. 474, 1439-1451
doi. 10.1042/BCJ20160498, 2017
PMID 28408429
PMC 5390927
Williams, C. A. C., Gray, N. S. and Findlay, G. M. (2017) A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening. J Vis Exp.
doi. 10.3791/55515, 2017
PMID 28570543
PMC 5607952
Zhang, C. S., Hawley, S. A., Zong, Y., Li, M., Wang, Z., Gray, A., Ma, T., Cui, J., Feng, J. W., Zhu, M., Wu, Y. Q., Li, T. Y., Ye, Z., Lin, S. Y., Yin, H., Piao, H. L., Hardie, D. G. and Lin, S. C. (2017) Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 548, 112-116
doi. 10.1038/nature23275, 2017
PMID 28723898
PMC 5544942
Zhang, J., Macartney, T., Peggie, M. and Cohen, P. (2017) Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem. J. 474, 2235-2248
doi. 10.1042/BCJ20170288, 2017
PMID 28507161
PMC 5632801
Zibrova, D., Vandermoere, F., Goransson, O., Peggie, M., Marino, K. V., Knierim, A., Spengler, K., Weigert, C., Viollet, B., Morrice, N. A., Sakamoto, K. and Heller, R. (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem. J. 474, 983-1001
doi. 10.1042/BCJ20160980, 2017
PMID 28008135