University of Dundee

Cell Signalling and Immunology 2012

Aregger, M. and Cowling, V. H. (2012) E2F1-dependent methyl cap formation requires RNA pol II phosphorylation. Cell Cycle. 11, 2146-2148
doi. 10.4161/cc.20620
Pubmed. 22592528

Berglund, F. M., Weerasinghe, N. R., Davidson, L., Lim, J. C., Eickholt, B. J. and Leslie, N. R. (2012) Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110alpha/PIK3CA but not by HER2 or mutant AKT1. Oncogene
doi. 10.1038/onc.2012.459
Pubmed. 23085752

Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. and Rena, G. (2012) The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a. The Biochemical journal. 443, 57-64
doi. 10.1042/BJ20112124
Pubmed. 22248233

Correa, S. A., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G., Pankratov, Y., Arthur, J. S. and Frenguelli, B. G. (2012) MSK1 regulates homeostatic and experience-dependent synaptic plasticity. J Neurosci. 32, 13039-13051
doi. 10.1523/JNEUROSCI.0930-12.2012
Pubmed. 22993422

Crocker, P. R., McMillan, S. J. and Richards, H. E. (2012) CD33-related siglecs as potential modulators of inflammatory responses. Annals of the New York Academy of Sciences. 1253, 102-111
doi. 10.1111/j.1749-6632.2011.06449.x
Pubmed. 22352893

Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H. W., Leslie, N. R., van Aalten, D. M., Downes, C. P. and Batty, I. H. (2012) IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. The Journal of biological chemistry. 287, 22483-22496
doi. 10.1074/jbc.M112.352773
Pubmed. 22493426

Evans, A. M., Peers, C., Wyatt, C. N., Kumar, P. and Hardie, D. G. (2012) Ion Channel Regulation by the LKB1-AMPK Signalling Pathway: The Key to Carotid Body Activation by Hypoxia and Metabolic Homeostasis at the Whole Body Level. Adv Exp Med Biol. 758, 81-90
doi. 10.1007/978-94-007-4584-1_11
Pubmed. 23080146

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. and Cantrell, D. A. (2012) PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med
doi. 10.1084/jem.20112607
Pubmed. 23183047

Grima, R., Schmidt, D. R. and Newman, T. J. (2012) Steady-state fluctuations of a genetic feedback loop: an exact solution. J Chem Phys. 137, 035104
doi. 10.1063/1.4736721
Pubmed. 22830733

Hardie, D. G. (2012) Organismal carbohydrate and lipid homeostasis. Cold Spring Harbor perspectives in biology. 4
doi. 10.1101/cshperspect.a006031
Pubmed. 22550228

Hardie, D. G., Ross, F. A. and Hawley, S. A. (2012) AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews. Molecular cell biology. 13, 251-262
doi. 10.1038/nrm3311
Pubmed. 22436748

Hardie, D. G., Ross, F. A. and Hawley, S. A. (2012) AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern. Chemistry & biology. 19, 1222-1236
doi. 10.1016/j.chembiol.2012.08.019
Pubmed. 23102217

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. and Hardie, D. G. (2012) The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 336, 918-922
doi. 10.1126/science.1215327
Pubmed. 22517326

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. and Mackintosh, C. (2012) ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase. Journal of cell science
doi. 10.1242/jcs.110296
Pubmed. 22797923

Klaas, M. and Crocker, P. R. (2012) Sialoadhesin in recognition of self and non-self. Seminars in immunopathology. 34, 353-364
doi. 10.1007/s00281-012-0310-3
Pubmed. 22450957

Klaas, M., Oetke, C., Lewis, L. E., Erwig, L. P., Heikema, A. P., Easton, A., Willison, H. J. and Crocker, P. R. (2012) Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol. 189, 2414-2422
doi. 10.4049/jimmunol.1200776
Pubmed. 22851711

Lee, C. W., Wong, L. L., Tse, E. Y., Liu, H. F., Leong, V. Y., Lee, J. M., Hardie, D. G., Ng, I. O. and Ching, Y. P. (2012) AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res. 72, 4394-4404
doi. 10.1158/0008-5472.CAN-12-0429
Pubmed. 22728651

Leslie, N. R. (2012) PTEN: An Intercellular Peacekeeper? Science signaling. 5, pe50
doi. 10.1126/scisignal.2003685
Pubmed. 23150879

Leslie, N. R., Davies, E. M., Sheffield, D. A., Tibarewal, P., Fedele, C. G. and Mitchell, C. A. (2012) The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease. Sub-cellular biochemistry. 58, 281-336
doi. 10.1007/978-94-007-3012-0_8
Pubmed. 22403079

Lipina, C., Rastedt, W., Irving, A. J. and Hundal, H. S. (2012) New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance. BioEssays : news and reviews in molecular, cellular and developmental biology. 34, 681-691
doi. 10.1002/bies.201200031
Pubmed. 22674489

Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. and Rena, G. (2012) Cellular responses to the metal-binding properties of metformin. Diabetes. 61, 1423-1433
doi. 10.2337/db11-0961
Pubmed. 22492524

Martin, K. J. and Arthur, J. S. (2012) Selective kinase inhibitors as tools for neuroscience research. Neuropharmacology. 63, 1227-1237
doi. 10.1016/j.neuropharm.2012.07.024
Pubmed. 22846224

Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Gornemann, J., Beullens, M., Bollen, M., Forrester, J. V. and McCaig, C. D. (2012) A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells. PloS one. 7, e40769
doi. 10.1371/journal.pone.0040769
Pubmed. 22815811

Matthews, S. A., San Lek, H., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. and Fagerholm, S. C. (2012) Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues. Eur J Immunol. 42, 1316-1326
doi. 10.1002/eji.201142004
Pubmed. 22311617

Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. and Cantrell, D. A. (2012) Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells. The Biochemical journal. 442, 649-659
doi. 10.1042/BJ20111700
Pubmed. 22233340

Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. and van Aalten, D. M. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. The EMBO journal. 31, 1394-1404
doi. 10.1038/emboj.2012.8
Pubmed. 22307082

Pattison, M. J., Mackenzie, K. F. and Arthur, J. S. (2012) Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol. 189, 2784-2792
doi. 10.4049/jimmunol.1200310
Pubmed. 22904308

Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. and Anichini, A. (2012) AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway. Melanoma Res. 22, 341-350
doi. 10.1097/CMR.0b013e3283544929
Pubmed. 22588166

Qu, B., Landsbury, A., Schonthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. and Quinlan, R. A. (2012) Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue. Experimental eye research. 94, 192-202
doi. 10.1016/j.exer.2011.12.001
Pubmed. 22182672

Schimpl, M., Borodkin, V. S., Gray, L. J. and van Aalten, D. M. (2012) Synergy of peptide and sugar in O-GlcNAcase substrate recognition. Chemistry & biology. 19, 173-178
doi. 10.1016/j.chembiol.2012.01.011
Pubmed. 22365600

Thompson, A. M. and Newman, T. J. (2012) Milking the stroma in triple-negative breast cancer. Cell Cycle. 11, 1487
doi. 10.4161/cc.20049
Pubmed. 22544077

Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. and Leslie, N. R. (2012) PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Science signaling. 5, ra18
doi. 10.1126/scisignal.2002138
Pubmed. 22375056

Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. and Hundal, H. S. (2012) Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells. The Journal of biological chemistry. 287, 20088-20099
doi. 10.1074/jbc.M111.330746
Pubmed. 22511782

Watts, C. (2012) The endosome-lysosome pathway and information generation in the immune system. Biochimica et biophysica acta. 1824, 14-21
doi. 10.1016/j.bbapap.2011.07.006
Pubmed. 21782984

Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. and Pearson, E. (2012) The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 44, 361-362
doi. 10.1038/ng.2234
Pubmed. 22456734