University of Dundee

Biological Chemistry and Drug Discovery 2018

Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A. 2018. Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach. ACS Chemical Biology. 13(4):915-921. https://doi.org/10.1021/acschembio.7b01093

Aresu L, Ferraresso S, Marconato L, Cascione L, Napoli S, Gaudio E, Kwee I, Tarantelli C, Testa A, Maniaci C, Ciulli A, Hillmann P, Bohnacker T, Wymann MP, Comazzi S, Milan M, Riondato F, Dalla Rovere G, Giantin M, Giannuzzi D, Bertoni F. 2018. New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease. Haematologica. https://doi.org/10.3324/haematol.2018.207027

Bell M, Foley D, Naylor C, Robinson C, Riley J, Epemolu R, Scullion S, Shishikura Y, Katz E, McLean W, Wyatt P, Read K, Woodland C. 2018. Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1. Bioorganic & Medicinal Chemistry Letters. https://doi.org/10.1016/j.bmcl.2018.07.044

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK. 2018. The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1. ChemBioChem. 19(5):425-429. https://doi.org/10.1002/cbic.201700500

Castro G, Ciulli A. 2018. Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment. Chemical Communications.

Hallyburton I, Zuccotto F, Wyatt P, De Rycker M, Horn D, Ferguson M, Clos J, Read K, Fairlamb A, Gilbert I, Wyllie S. 2018. Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.8b00226

Chan KH, Zengerle M, Testa A, Ciulli A. 2018. Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. Journal of Medicinal Chemistry. 61(2):504-513. https://doi.org/10.1021/acs.jmedchem.6b01912

Corpas Lopez V, Moniz S, Thomas M, Wall R, Torrie L, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt P, De Rycker M, Horn D, Ferguson M, Clos J, Read K, Fairlamb A, Gilbert I, Wyllie S. 2018. Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.8b00226

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. 2018. Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei. Molecular & Cellular Proteomics. 17:1184-1195. https://doi.org/10.1074/mcp.RA118.000650

Cleghorn L, Ray P, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu R, Zuccotto F, Riley J, Scullion S, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read K, Green S, Hipskind P, Parish T, Wyatt P. 2018. Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.8b00172

Dacks JB, Field MC. 2018. Evolutionary origins and specialisation of membrane transport. Current Opinion in Cell Biology. 53:70-76. https://doi.org/10.1016/j.ceb.2018.06.001

De Rycker M, Baragaña B, Duce SL, Gilbert IH. 2018. Challenges and recent progress in drug discovery for tropical diseases. Nature. 559(7715):498-506. https://doi.org/10.1038/s41586-018-0327-4

Fairlamb A, Horn D. 2018. Melarsoprol Resistance in African Trypanosomiasis. Trends in Parasitology. 34(6):481-492. https://doi.org/10.1016/j.pt.2018.04.002

Fairlamb AH, Patterson S. 2018. Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. Current Medicinal Chemistry. https://doi.org/10.2174/0929867325666180426164352

Fersing C, Boudot C, Pedron J, Hutter S, Primas N, Castera-Ducros C, Bourgeade-Delmas S, Sournia-Saquet A, Moreau A, Cohen A, Stigliani J-L, Pratviel G, Crozet MD, Wyllie S, Fairlamb A, Valentin A, Rathelot P, Azas N, Courtioux B, Verhaeghe P, Vanelle P. 2018. 8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases. European Journal of Medicinal Chemistry. 157:115-126. https://doi.org/10.1016/j.ejmech.2018.07.064

Gilbert I. 2018. Substituted aminoacetamides as novel leads for the potential treatment of malaria. ChemMedChem. https://doi.org/10.1002/cmdc.201800616

Gottschald Chiodi C, Baptista-Hon D, Hunter W, Hales T. 2018. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA118.006229

Harrison JR, Brand S, Smith V, Robinson DA, Thompson S, Smith A, Davies K, Mok N, Torrie LS, Collie I, Hallyburton I, Norval S, Simeons FRC, Stojanovski L, Frearson JA, Brenk R, Wyatt PG, Gilbert IH, Read KD. 2018. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. Journal of Medicinal Chemistry. 61(18):8374–8389. https://doi.org/10.1021/acs.jmedchem.8b00884

Herman EK, Ali M, Field MC, Dacks JB. 2018. Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins. Traffic. https://doi.org/10.1111/tra.12570

Holden JM, Koreny L, Obado S, Ratushny AV, Chen W-M, Bart J-M, Navarro M, Chait BT, Aitchison JD, Rout MP, Field MC. 2018. Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes. Molecular Biology of the Cell. 29(9). https://doi.org/10.1091/mbc.E17-06-0430

Hulshof L, Hack DP, Hasnoe QCJ, Dontje B, Jakasa I, Riethmüller C, McLean WHI, van Aalderen WMC, Van't Land B, Kezic S, Sprikkelman AB, Middelkamp-Hup MA. 2018. A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis. British Journal of Dermatology. https://doi.org/10.1111/bjd.16994

Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, O'Neill L, Rosala-Hallas A, Sach T, Spowart C, Taams L, Walker C, Wan M, Webb N, Williamson P, Flohr C. 2018. A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT). British Journal of Dermatology. 179(6):1297-1306. https://doi.org/10.1111/bjd.16717

Jeacock L, Correia Faria J, Horn D. 2018. Codon usage bias controls mRNA and protein abundance in trypanosomatids. eLife. https://doi.org/10.7554/eLife.32496

Kelner A, Tinti M, Guther M, Foth BJ, Chappell L, Berriman M, Cowling V, Ferguson M. 2018. The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei. PLoS ONE. 13(7). https://doi.org/10.1371/journal.pone.0201263

Kono M, Akiyama M, Inoue Y, Nomura T, Hata A, Okamoto Y, Takeichi T, Muro Y, McLean WHI, Shimizu H, Sugiura K, Suzuki Y, Shimojo N. 2018. Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children. British Journal of Dermatology. https://doi.org/10.1111/bjd.16375

Kovarova J, Nagar R, Correia Faria J, Ferguson M, Barrett MP, Horn D. 2019. Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens. 15(1):1-22. https://doi.org/10.1371/journal.ppat.1007475

Kürklü E, Öztürk Ş, Cassidy AJ, Ak G, Koray M, Çefle K, Palandüz Ş, Güllüoğlu MG, Tanyeri H, McLean WHI. 2018. Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus. Medicina Oral Patologia Oral y Cirugia Bucal. 23(2):e144-e150. https://doi.org/10.4317/medoral.21437

Liu D, Albergante L, Newman T, Horn D. 2018. Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites. Scientific Reports. 8:1-10. https://doi.org/10.1038/s41598-018-29296-8

Lucas X, van Molle I, Ciulli A. 2018. Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.8b00842

Luise N, Wyatt P. 2018. Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug Discovery Campaigns. Chemistry: a European Journal. 24(41):10443-10451. https://doi.org/10.1002/chem.201801313

Luise N, Wyatt PG. 2018. Diversity-oriented synthesis of bicyclic fragments containing privileged azines. Bioorganic & Medicinal Chemistry Letters. https://doi.org/10.1016/j.bmcl.2018.11.046

Luise N, Wyatt EW, Tarver G, Wyatt P. 2018. A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments. European Journal of Organic Chemistry.

McKenzie C, Sutcliffe OB, Read K, Scullion S, Epemolu R, Fletcher D, Helander A, Beck O, Rylski A, Antonides L, Riley J, Smith S, Nic Daeid N. 2018. Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and it's newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users. Forensic Toxicology. 36(2):359-374. https://doi.org/10.1007/s11419-018-0413-1

MacLean L, Thomas J, Lewis MD, Cotillo I, Gray D, De Rycker M. 2018. Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery. PLoS Neglected Tropical Diseases. 12(7):1-22. https://doi.org/10.1371/journal.pntd.0006612

Martinez-Fabregas J, Prescott A, van Kasteren S, Leslie Pedrioli D, McLean W, Moles A, Reinheckel T, Poli V, Watts C. 2018. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nature Communications. 9(1). https://doi.org/10.1038/s41467-018-07741-6

McAleer MA, Jaska I, Raj N, O'Donnell CPF, Lane ME, Rawlings AV, Voegeli R, McLean W, Kezic S, Irvine AD. 2018. Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: Implications for atopic dermatitis. British Journal of Dermatology. 179(2):431-441. https://doi.org/10.1111/bjd.16691

McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean W, Tanaka RJ, Kezic S, Irvine AD. 2018. Systemic and stratum corneum biomarkers of severity in infant AD include markers of innate and Th-related immunity and angiogenesis. British Journal of Dermatology. https://doi.org/10.1111/bjd.17088

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares De Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE, Wyatt PG, Boshoff HIM. 2018. 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS Infectious Diseases. 4(6):954-969. https://doi.org/10.1021/acsinfecdis.7b00275

Navratilova IH, Aristotelous T, Bird LE, Hopkins AL. 2018. Surveying GPCR solubilisation conditions using surface plasmon resonance. Analytical Biochemistry. 556:23-34. https://doi.org/10.1016/j.ab.2018.06.012

Ohguchi Y, Nomura T, Suzuki S, Takeda M, Miyauchi T, Mizuno O, Shinkuma S, Fujita Y, Nemoto O, Ono K, McLean WHI, Shimizu H. 2018. Gentamicin-induced readthrough and nonsense-mediated mRNA decay of SERPINB7 nonsense mutant transcripts. Journal of Investigative Dermatology. 138(4):836-843. https://doi.org/10.1016/j.jid.2017.10.014

Owen RA, Fyfe PK, Lodge A, Biboy J, Vollmer W, Hunter WN, Sargent F. 2018. Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens. Biochemical Journal. 475(2):415-428. https://doi.org/10.1042/BCJ20170633

Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani J-L, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P. 2018. Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. European Journal of Medicinal Chemistry. 155:135-152. https://doi.org/10.1016/j.ejmech.2018.06.001

Pedron J, Boudot C, Bourgeade-Delmas S, Sournia-Saquet A, Paloque L, Rastegari M, Abdoulaye M, El-Kashef H, Bonduelle C, Pratviel G, Wyllie S, Fairlamb AH, Courtioux B, Verhaeghe P, Valentin A. 2018. Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions. ChemMedChem. 13(20):2217-2228. https://doi.org/10.1002/cmdc.201800456

Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MB, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP. 2018. Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and additional risk genes. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2018.05.013

Pinger J, Nešić D, Ali L, Aresta-Branco F, Lilic M, Chowdhury S, Kim HS, Verdi J, Raper J, Ferguson MAJ, Papavasiliou FN, Stebbins CE. 2018. African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nature Microbiology. 3(8):932-938. https://doi.org/10.1038/s41564-018-0187-6

Portnoi M-F, Dumargne M-C, Rojo S, Witchel SF, Duncan AJ, Eozenou C, Bignon-Topalovic J, Yatsenko SA, Rajkovic A, Reyes-Mugica M, Almstrup K, Fusee L, Srivastava Y, Chantot-Bastaraud S, Hyon C, Louis-Sylvestre C, Validire P, de Malleray Pichard C, Ravel C, Christin-Maitre S, Brauner R, Rossetti R, Persani L, Charreau EH, Dain L, Chiauzzi VA, Mazen I, Rouba H, Schluth-Bolard C, MacGowan S, McLean WHI, Patin E, Rajpert-De Meyts E, Jauch R, Achermann JC, Siffroi J-P, McElreavey K, Bashamboo A. 2018. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. Human Molecular Genetics. 27(7):1228-1240. https://doi.org/10.1093/hmg/ddy037

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, Encinas L, Zeng J, Chung C-W, De Dios Anton P, Mendoza-Losana A, Mackenzie C, Green SR, Huggett M, Barros D, Wyatt PG, Ray PC. 2018. Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA. ChemMedChem. 13(7):672-677. https://doi.org/10.1002/cmdc.201700774

Quintana JF, Canavate Del Pino R, Yamada K, Zhang N, Field M. 2018. Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes. Genes. 9(7). https://doi.org/10.3390/genes9070368

Rico Vidal E, Jeacock L, Kovarova J, Horn D. 2018. Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes. Scientific Reports. 8:1-10. https://doi.org/1038/s41598-018-26303-w

Roberts A, Dunne J, Scullion S, Norval S, Fairlamb A. 2018. A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism. Biochemical Journal. 475(16):2593-2610. https://doi.org/10.1042/BCJ20180232

Roekevisch E, Leeflang MMG, Schram ME, Campbell LE, Irwin McLean WH, Kezic S, Bos JD, Spuls PI, Middelkamp-Hup MA. 2018. Patients with filaggrin loss-of-function mutations show good but lower responses to immunosuppressive treatment. British Journal of Dermatology. 177(6):1745-1746. https://doi.org/10.1111/bjd.15191

Runcie A, Zengerle M, Chan KH, Testa A, Van Beurden L, Baud M, Epemolu R, Ellis L, Read K, Coulthard V, Brien A, Ciulli A. 2018. Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition. Chemical Science. 2018(9):2387-2634. https://doi.org/10.1039/C7SC02536J

Sienkiewicz N, Ong H, Fairlamb A. 2018. Characterisation of a putative glutamate 5‐kinase from Leishmania donovani. FEBS Journal. https://doi.org/10.1111/febs.14511

Soares P, Lucas X, Ciulli A. 2018. Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorganic & Medicinal Chemistry. 26(11):2992-2995. https://doi.org/10.1016/j.bmc.2018.03.034

Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, Epemolu O. 2018. Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past to Help Discover Long-Acting Oral Drugs in the Future. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.8b00160

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP. 2018. Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases. 12(5):1-24. https://doi.org/10.1371/journal.pntd.0006450

Testa A, Lucas X, Castro G, Chan KH, Wright J, Runcie A, Gadd M, Harrison WTA, Ko EJ, Fletcher D, Ciulli A. 2018. 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation. Journal of the American Chemical Society. 140(29):9299-9313. https://doi.org/10.1021/jacs.8b05807

Thomas MG, De Rycker M, Cotillo Torrejon I, Thomas J, Riley J, Spinks D, Read KD, Miles TJ, Gilbert IH, Wyatt PG. 2018. 2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease. Bioorganic & Medicinal Chemistry Letters. 28(18):3025-3030. https://doi.org/10.1016/j.bmcl.2018.08.005

Thomas MG, De Rycker M, Ajakane M, Albrecht S, Álvarez-Pedraglio AI, Boesche M, Brand S, Campbell L, Cantizani-Perez J, Cleghorn LAT, Copley RCB, Crouch SD, Daugan A, Drewes G, Ferrer S, Ghidelli-Disse S, Gonzalez S, Gresham SL, Hill AP, Hindley SJ, Lowe RM, MacKenzie CJ, MacLean L, Manthri S, Martin F, Miguel-Siles J, Nguyen VL, Norval S, Osuna-Cabello M, Woodland A, Patterson S, Pena I, Quesada-Campos MT, Reid IH, Revill C, Riley J, Ruiz-Gomez JR, Shishikura Y, Simeons FRC, Smith A, Smith VC, Spinks D, Stojanovski L, Thomas J, Thompson S, Underwood T, Gray DW, Fiandor JM, Gilbert IH, Wyatt PG, Read KD, Miles TJ. 2018. Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.8b01218

Thomas J, Baker N, Dominicus C, Trenaman A, Glover L, Alsford S, Horn D. 2018. Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. PLoS Neglected Tropical Diseases. 12(11):1-19. https://doi.org/10.1371/journal.pntd.0006980

Venkatesh D, Zhang N, Zoltner M, Canavate Del Pino R, Field MC. 2018. Evolution of protein trafficking in kinetoplastid parasites: complexity and pathogenesis. Traffic. 19(11):803-812. https://doi.org/10.1111/tra.12601

Wall R, Moniz S, Thomas M, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert I, Horn D, Fairlamb A, Wyllie S. 2018. Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals. Antimicrobial Agents and Chemotherapy. 62(8). https://doi.org/10.1128/AAC.00235-18

Wall R, Rico Vidal E, Lukac I, Zuccotto F, Elg S, Gilbert I, Freund YR, Alley MRK, Field M, Wyllie S, Horn D. 2018. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Proceedings of the National Academy of Sciences of the United States of America. 115(38):9616-9621. https://doi.org/10.1073/pnas.1807915115

Webster L, Thomas M, Urbaniak M, Wyllie S, Ong H, Tinti M, Fairlamb A, Boesche M, Ghidelli-Disse S, Drewes G, Gilbert I. 2018. Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome. ACS Infectious Diseases. 4(10):1475-1486. https://doi.org/10.1021/acsinfecdis.8b00097

Wong XFCC, Denil SLIJ, Foo JN, Chen H, Ling Tay AS, Haines RL, Tang MBY, McLean WHI, Sandilands A, Smith FJD, Lane EB, Liu J, Common JEA. 2018. Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants. Journal of Allergy and Clinical Immunology. 141(2):814-816. https://doi.org/10.1016/j.jaci.2017.10.001

Wu D, Struwe WB, Harvey DJ, Ferguson MAJ, Robinson CV. 2018. N-glycan microheterogeneity regulates interactions of plasma proteins. Proceedings of the National Academy of Sciences of the United States of America. 115(38). https://doi.org/10.1073/pnas.1807439115

Wyllie S, Thomas M, Patterson S, Crouch S, De Rycker M, Lowe R, Gresham S, Urbaniak MD, Otto TD, Stojanovski L, Simeons FRC, Manthri S, MacLean LM, Zuccotto F, Homeyer N, Pflaumer H, Boesche M, Sastry L, Connolly P, Albrecht S, Berriman M, Drewes G, Gray DW, Ghidelli-Disse S, Dixon S, Fiandor JM, Wyatt PG, Ferguson MAJ, Fairlamb AH, Miles TJ, Read KD, Gilbert IH. 2018. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Nature. 560(7717):192-197. https://doi.org/10.1038/s41586-018-0356-z

Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang Y-K, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC. 2018. Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens. 14(2):1-25. https://doi.org/10.1371/journal.ppat.1006850

Zoltner M, Krienitz N, Field MC, Kramer S. 2018. Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PLoS Neglected Tropical Diseases. 12(7):1-18. https://doi.org/10.1371/journal.pntd.0006679

Zoppi V, Hughes SJ, Maniaci C, Testa A, Gmaschitz T, Wieshofer C, Koegl M, Riching KM, Daniels DL, Spallarossa A, Ciulli A. 2018. Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.8b01413

 

Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A. 2018. Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach. ACS Chemical Biology. 13(4):915-921. Available from: 10.1021/acschembio.7b01093

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK. 2018. The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1. ChemBioChem. 19(5):425-429. Available from: 10.1002/cbic.201700500

Chan KH, Zengerle M, Testa A, Ciulli A. 2018. Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. Journal of Medicinal Chemistry. 61(2):504-513. Available from: 10.1021/acs.jmedchem.6b01912

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. 2018. Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei. Molecular & Cellular Proteomics. 17:1184-1195. Available from: 10.1074/mcp.RA118.000650

Dacks JB, Field MC. 2018. Evolutionary origins and specialisation of membrane transport. Current Opinion in Cell Biology. 53:70-76. Available from: 10.1016/j.ceb.2018.06.001

de Vos IJHM, Tao EY, Ong SLM, Goggi JL, Scerri T, Wilson GR, Low CGM, Wong ASW, Grussu D, Stegmann APA, van Geel M, Janssen R, Amor DJ, Bahlo M, Dunn NR, Carney TJ, Lockhart PJ, Coull B, van Steensel M. 2018. Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype. Human Molecular Genetics. Available from: 10.1093/hmg/ddy168

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