Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. and Urbaniak, M. D. (2012) Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness. Chemical biology & drug design. 79, 270-278
doi; 10.1111/j.1747-0285.2011.01300.x
PMC22222041
Alsford, S., duBois, K., Horn, D. and Field, M. C. (2012) Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes. Expert Rev Mol Med. 14, e13
doi; 10.1017/erm.2012.7
PMC22640744
Bandini, G., Marino, K., Guther, M. L., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. and Ferguson, M. A. (2012) Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase. Molecular microbiologydoi; 10.1111/j.1365-2958.2012.08124.x
PMC22676716
Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X. P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H., Roth, B. L. and Hopkins, A. L. (2012) Automated design of ligands to polypharmacological profiles. Nature. 492, 215-220
doi; 10.1038/nature11691
PMID;3653568 PMC23235874
Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. and Hopkins, A. L. (2012) Quantifying the chemical beauty of drugs. Nature chemistry. 4, 90-98
doi; 10.1038/nchem.1243
PMC22270643
Boisvert, F. M., Ahmad, Y., Gierlinski, M., Charriere, F., Lamont, D., Scott, M., Barton, G. and Lamond, A. I. (2012) A quantitative spatial proteomics analysis of proteome turnover in human cells. Mol Cell Proteomics. 11, M111 011429
doi; 10.1074/mcp.M111.011429
PMID;3316722 PMC21937730
Brand, S., Cleghorn, L. A., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A., Read, K. D., Wyatt, P. G. and Gilbert, I. H. (2012) Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem. 55, 140-152
doi; 10.1021/jm201091t
PMID;3256935 PMC22148754
Brenk, R. and Rauh, D. (2012) Change or be changed: Reflections of the workshop 'Future in Medicinal Chemistry'. Bioorganic & medicinal chemistry. 20, 3695-3697
doi; 10.1016/j.bmc.2012.04.038
PMC22607881
Capes, A., Patterson, S., Wyllie, S., Hallyburton, I., Collie, I. T., McCarroll, A. J., Stevens, M. F., Frearson, J. A., Wyatt, P. G., Fairlamb, A. H. and Gilbert, I. H. (2012) Quinol derivatives as potential trypanocidal agents. Bioorg Med Chem. 20, 1607-1615
doi; 10.1016/j.bmc.2011.12.018
PMID;3281193 PMC22264753
Coulthurst, S. J., Dawson, A., Hunter, W. N. and Sargent, F. (2012) Conserved signal peptide recognition systems across the prokaryotic domains. Biochemistry. 51, 1678-1686
doi; 10.1021/bi201852d
PMID;3290102 PMC22289056
Cui, H., Carrero-Lerida, J., Silva, A. P., Whittingham, J. L., Brannigan, J. A., Ruiz-Perez, L. M., Read, K. D., Wilson, K. S., Gonzalez-Pacanowska, D. and Gilbert, I. H. (2012) Synthesis and evaluation of alpha-thymidine analogues as novel antimalarials. J Med Chem. 55, 10948-10957
doi; 10.1021/jm301328h
PMID;3530961 PMC23240776
Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. and Burchmore, R. (2012) Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. J Proteomics. 75, 1463-1471
doi; 10.1016/j.jprot.2011.11.018
PMC22154982
De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. and Fairlamb, A. H. (2012) A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes. PLoS Negl Trop Dis. 6, e1932
doi; 10.1371/journal.pntd.0001932
PMID;3510075 PMC23209868
Eadsforth, T. C., Cameron, S. and Hunter, W. N. (2012) The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target. Mol Biochem Parasitol. 181, 178-185
doi; 10.1016/j.molbiopara.2011.11.004
PMID;3368264 PMC22108435
Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. and Hunter, W. N. (2012) Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target. PLoS One. 7, e35973
doi; 10.1371/journal.pone.0035973
PMID;3338484 PMC22558288
Eadsforth, T. C., Maluf, F. V. and Hunter, W. N. (2012) Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571. FEBS J. 279, 4350-4360
doi; 10.1111/febs.12025
PMID;3655515 PMC23050773
Fairlamb, A. H. (2012) Infectious disease: Genomics decodes drug action. Nature. 482, 167-169
doi; 10.1038/482167a
PMC22318598
Ferguson, M. A. and Anderson, J. S. (2012) Dynamical stability of intrinsic connectivity networks. Neuroimage. 59, 4022-4031
doi; 10.1016/j.neuroimage.2011.10.062
PMID;3288774 PMC22056459
Fyfe, P. K., Westrop, G. D., Ramos, T., Muller, S., Coombs, G. H. and Hunter, W. N. (2012) Structure of Leishmania major cysteine synthase. Acta crystallographica. Section F, Structural biology and crystallization communications. 68, 738-743
doi; 10.1107/S1744309112019124
PMC22750854
Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. and Hunter, W. N. (2012) Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proceedings of the National Academy of Sciences of the United States of Americadoi; 10.1073/pnas.1202593109
PMC22753509
Han, J., Miranda-Saavedra, D., Luebbering, N., Singh, A., Sibbet, G., Ferguson, M. A. and Cleghon, V. (2012) Deep evolutionary conservation of an intramolecular protein kinase activation mechanism. PLoS One. 7, e29702
doi; 10.1371/journal.pone.0029702
PMID;3250476 PMC22235329
Hudson, S. A., McLean, K. J., Surade, S., Yang, Y. Q., Leys, D., Ciulli, A., Munro, A. W. and Abell, C. (2012) Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. Angew Chem Int Ed Engl. 51, 9311-9316
doi; 10.1002/anie.201202544
PMC22890978
Izquierdo, L., Mehlert, A. and Ferguson, M. A. (2012) The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases. Glycobiology. 22, 696-703
doi; 10.1093/glycob/cws003
PMID;3311286 PMC22241825
Jones, D. C., Alphey, M. S., Wyllie, S. and Fairlamb, A. H. (2012) Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome. Mol Microbiol. 86, 51-64
doi; 10.1111/j.1365-2958.2012.08189.x
PMID;3470933 PMC22857512
Kuettel, S., Wadum, M. C., Guther, M. L., Marino, K., Riemer, C. and Ferguson, M. A. (2012) The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei. Molecular microbiology. 84, 340-351
doi; 10.1111/j.1365-2958.2012.08026.x
PMC22375793
Mehlert, A., Wormald, M. R. and Ferguson, M. A. (2012) Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei. PLoS pathogens. 8, e1002618
doi; 10.1371/journal.ppat.1002618
PMID;3320590 PMC22496646
Miranda-Saavedra, D., Gabaldon, T., Barton, G. J., Langsley, G. and Doerig, C. (2012) The kinomes of apicomplexan parasites. Microbes Infect. 14, 796-810
doi; 10.1016/j.micinf.2012.04.007
PMC22587893
Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. and Chubb, J. R. (2012) Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation. Proceedings of the National Academy of Sciences of the United States of America. 109, 7350-7355
doi; 10.1073/pnas.1117603109
PMID;3358836 PMC22529358
Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. and Cook, A. (2012) Biosensor-based approach to the identification of protein kinase ligands with dual-site modes of action. J Biomol Screen. 17, 183-193
doi; 10.1177/1087057111422746
PMC22068706
Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. and Bickle, Q. D. (2012) Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. PLoS Negl Trop Dis. 6, e1762
doi; 10.1371/journal.pntd.0001762
PMID;3409125 PMC22860151
Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J., Goh, C. S., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M., Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. and McLean, W. H. (2012) Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. Nat Genet. 44, 1272-1276
doi; 10.1038/ng.2444
PMID;3836166 PMC23064416
Ramasamy, R. and Field, M. C. (2012) Terminal galactosylation of glycoconjugates in Plasmodium falciparum asexual blood stages and Trypanosoma brucei bloodstream trypomastigotes. Exp Parasitol. 130, 314-320
doi; 10.1016/j.exppara.2012.02.017
PMC22406352
Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. and Lamond, A. I. (2012) Human box C/D snoRNA processing conservation across multiple cell types. Nucleic Acids Res. 40, 3676-3688
doi; 10.1093/nar/gkr1233
PMID;3333852 PMC22199253
Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. and Simpson, G. G. (2012) Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation. Nat Struct Mol Biol. 19, 845-852
doi; 10.1038/nsmb.2345
PMID;3533403 PMC22820990
Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. and Gilbert, I. H. (2012) Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors. ChemMedChem. 7, 95-106
doi; 10.1002/cmdc.201100420
PMID;3320663 PMC22162199
Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. and Leslie, N. R. (2012) PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci Signal. 5, ra18
doi; 10.1126/scisignal.2002138
PMC22375056
Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. and Brenk, R. (2012) IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening. PloS one. 7, e35792
doi; 10.1371/journal.pone.0035792
PMID;3340893 PMC22563402
Urbaniak, M. D., Guther, M. L. and Ferguson, M. A. (2012) Comparative SILAC Proteomic Analysis of Trypanosoma brucei Bloodstream and Procyclic Lifecycle Stages. PloS one. 7, e36619
doi; 10.1371/journal.pone.0036619
PMID;3344917 PMC22574199
Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A., Frearson, J. and Drewes, G. (2012) Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei. ACS Chem Biol. 7, 1858-1865
doi; 10.1021/cb300326z
PMID;3621575 PMC22908928
Wullschleger, S., Garcia-Martinez, J. M. and Duce, S. L. (2012) Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma. Anticancer Res. 32, 415-420
doi; PMID;3292793 PMC22287727
Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R., Norval, S., Kime, R., Read, K. D. and Fairlamb, A. H. (2012) The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis. Sci Transl Med. 4, 119re111
doi; 10.1126/scitranslmed.3003326
PMID;3457684 PMC22301556