University of Dundee

2019

Baragaña, B, Forte, B, Choi, R, Nakazawa Hewitt, S, Bueren-Calabuig, JA, Pisco, JP, Peet, C, Dranow, DM, Robinson, DA, Jansen, C, Norcross, NR, Vinayak, S, Anderson, M, Brooks, CF, Cooper, CA, Damerow, S, Delves, M, Dowers, K, Duffy, J, Edwards, TE, Hallyburton, I, Horst, BG, Hulverson, MA, Ferguson, L, Jiménez-Díaz, MB, Jumani, RS, Lorimer, DD, Love, MS, Maher, S, Matthews, H, McNamara, CW, Miller, P, O'Neill, S, Ojo, KK, Osuna-Cabello, M, Pinto, E, Post, J , Riley, J, Rottmann, M, Sanz, LM, Scullion, P, Sharma, A, Shepherd, SM, Shishikura, Y, Simeons, FRC, Stebbins, EE, Stojanovski, L, Straschil, U, Tamaki, FK, Tamjar, J, Torrie, LS, Vantaux, A, Witkowski, B, Wittlin, S, Yogavel, M, Zuccotto, F, Angulo-Barturen, I, Sinden, R, Baum, J, Gamo, F-J, Mäser, P, Kyle, DE, Winzeler, EA, Myler, PJ, Wyatt, PG, Floyd, D, Matthews, D, Sharma, A, Striepen, B, Huston, CD, Gray, DW, Fairlamb, AH, Pisliakov, AV, Walpole, C, Read, KD, Van Voorhis, WC & Gilbert, IH 2019, 'Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis' Proceedings of the National Academy of Sciences, vol. 116, no. 14, pp. 7015-7020. https://doi.org/10.1073/pnas.1814685116

Bell, M, Foley, D, Naylor, C, Wood, G, Robinson, C, Riley, J, Epemolu, R, Ellis, L, Scullion, S, Shishikura, Y, OsunaCabello, M, Ferguson, L, Pinto, E, Fletcher, D, Katz, E, McLean, W, Wyatt, P, Read, K & Woodland, C 2019, 'Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)' ACS Medicinal Chemistry Letters, vol. 10, no. 3, pp. 341–347. https://doi.org/10.1021/acsmedchemlett.8b00616

Bueno, R, Dawson, A & Hunter, WN 2019, 'An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement' Acta Crystallographica Section F: Structural Biology Communications, vol. 75, no. Pt 3, pp. 148-152. https://doi.org/10.1107/S2053230X18018083

Castro, GVD & Ciulli, A 2019, 'Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment' Chemical Communications, vol. 55, no. 10, pp. 1482-1485. https://doi.org/10.1039/C8CC09790A

Collett, CF, Kitson, C, Baker, N, Steele-Stallard, HB, Santrot, M-V, Hutchinson, S, Horn, D & Alsford, S 2019, ' Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei' Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/AAC.00795-19

Corpas Lopez, V, Moniz, S, Thomas, M, Wall, R, Torrie, L, Zander-Dinse, D, Tinti, M, Brand, S, Stojanovski, L, Manthri, S, Hallyburton, I, Zuccotto, F, Wyatt, P, De Rycker, M, Horn, D, Ferguson, M, Clos, J, Read, K, Fairlamb, A, Gilbert, I & Wyllie, S 2019, 'Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani' ACS Infectious Diseases, vol. 5, no. 1, pp. 111-122. https://doi.org/10.1021/acsinfecdis.8b00226

Correia Faria, J, Glover, L, Hutchinson, S, Boehm, C, Field, M & Horn, D 2019, 'Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex' Nature Communications.

Ebenezer, T, Zoltner, M, Burrell, A, Nenarokova, A, Novák Vanclová, AMG, Prasad, B, Soukal, P, Santana-Molina, C, O'Neill, E, Nankissoor, NN, Vadakedath, N, Daiker, V, Obado, S, Silva-Pereira, S, Jackson, AP, Devos, DP, Lukeš, J, Lebert, M, Vaughan, S, Hampl, V, Carrington, M, Ginger, ML, Dacks, JB, Kelly, S & Field, M 2019, 'Transcriptome, proteome and draft genome of Euglena gracilis' BMC Biology, vol. 17, 11, pp. 1-23. https://doi.org/10.1186/s12915-019- 0626-8

Elhaji, Y, Sasseville, D, Pratt, M, Asai, Y, Matheson, K, McLean, WHI & Hull, P 2019, 'Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies' Contact Dermatitis. https://doi.org/10.1111/cod.13268

Fersing, C, Basmaciyan, L, Boudot, C, Pedron, J, Hutter, S, Cohen, A, Castera-Ducros, C, Primas, N, Laget, M, Casanova, M, Bourgeade-Delmas, S, Piednoel, M, Sournia-Saquet, A, Belle Mbou, V, Courtioux, B, Boutet-Robinet, É, Since, M, Milne, R, Wyllie, S, Fairlamb, AH, Valentin, A, Rathelot, P, Verhaeghe, P, Vanelle, P & Azas, N 2019, ' Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity' ACS Medicinal Chemistry Letters, vol. 10, no. 1, pp. 34-39. https://doi.org/10.1021/acsmedchemlett.8b00347

Field, MC & Rout, MP 2019, 'Pore timing: the evolutionary origins of the nucleus and nuclear pore complex' F1000Research, vol. 8, 369, pp. 1-11. https://doi.org/10.12688/f1000research.16402.1

Field, MC 2019, 'The kinetochore and the origin of eukaryotic chromosome segregation' Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1908067116

Ford, GA, Lord, JM, Ferguson, MAJ, Bountra, C & Le Couteur, DG 2019, 'Organizational innovation for developing new medicines that target aging and age-related conditions' The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, pp. 1-4. https://doi.org/10.1093/gerona/glz062

Frost, J, Ciulli, A & Rocha, S 2019, 'RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response' Wellcome Open Research, vol. 4, 17, pp. 1-17. https://doi.org/10.12688/wellcomeopenres.15044.1

Girardini, M, Maniaci, C, Hughes, S, Testa, A & Ciulli, A 2019, 'Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs' Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2019.02.048

Gottschald Chiodi, C, Baptista-Hon, D, Hunter, W & Hales, T 2019, 'Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA' Journal of Biological Chemistry, vol. 294, no. 7, pp. 2375-2385. https://doi.org/10.1074/jbc.RA118.006229

Kung, W-W, Ramachandran, S, Makukhin, N, Bruno, E & Ciulli, A 2019, 'Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase' Nature Communications.

Luise, N, Wyatt, EW, Tarver, G & Wyatt, P 2019, 'A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments' European Journal of Organic Chemistry, vol. 2019, no. 6, pp. 1341-1349. https://doi.org/10.1002/ejoc.201801684

Martin, J, Mackenzie, C, Fletcher, D & Gilbert, I 2019, 'Characterising Covalent Warhead Reactivity' Bioorganic & Medicinal Chemistry, vol. 27, no. 10, pp. 2066-2076. https://doi.org/10.1016/j.bmc.2019.04.002

Mattos, EC, Canuto, G, Varón, NCM, Magalhães, RDM, Crozier, TWM, Lamont, DJ, Tavares, MFM, Colli, W, Ferguson, MAJ & Alves, MJM 2019, 'Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix' PLoS Neglected Tropical Diseases, vol. 13, no. 2, e0007103, pp. 1-27. https://doi.org/10.1371/journal.pntd.0007103

Moitra, S, Pawlowic, MC, Hsu, F-F & Zhang, K 2019, 'Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major' Scientific Reports, vol. 9, 7602, pp. 1-13. https://doi.org/10.1038/s41598-019-44086-6

Pankov, G, Dawson, A & Hunter, WN 2019, 'The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei' Acta Crystallographica Section F: Structural Biology Communications, vol. 75, no. 4, pp. 227- 232. https://doi.org/10.1107/S2053230X19001778

Popow, J, Arnhof, H, Bader, G, Berger, H, Ciulli, A, Covini, D, Dank, C, Gmaschitz, T, Greb, P, Karolyi-Özguer, J, Koegl, M, McConnell, DB, Pearson, M, Rieger, M, Rinnenthal, J, Roessler, V, Schrenk, A, Spina, M, Steurer, S, Trainor, N, Traxler, E, Wieshofer, C, Zoephel, A & Ettmayer, P 2019, 'Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions' Journal of Medicinal Chemistry, vol. 62, no. 5, pp. 2508–2520. https://doi.org/10.1021/acs.jmedchem.8b01826

Prakash, O, Führing, J, Post, J, Shepherd, SM, Eadsforth, TC, Gray, D, Fedorov, R & Routier, FH 2019, 'Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening' Molecules and Cells, vol. 24, no. 5, 996, pp. 1-16. https://doi.org/10.3390/molecules24050996

Roy, M, Winkler, S, Hughes, SJ, Whitworth, C, Galant, M, Farnaby, W, Rumpel, K & Ciulli, A 2019, 'SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate' ACS Chemical Biology, vol. 14, no. 3, pp. 361-368. https://doi.org/10.1021/acschembio.9b00092

Thomas, MG, De Rycker, M, Ajakane, M, Albrecht, S, Álvarez-Pedraglio, AI, Boesche, M, Brand, S, Campbell, L, Cantizani-Perez, J, Cleghorn, LAT, Copley, RCB, Crouch, SD, Daugan, A, Drewes, G, Ferrer, S, Ghidelli-Disse, S, Gonzalez, S, Gresham, SL, Hill, AP, Hindley, SJ, Lowe, RM, MacKenzie, CJ, MacLean, L, Manthri, S, Martin, F, MiguelSiles, J, Nguyen, VL, Norval, S, Osuna-Cabello, M, Woodland, A, Patterson, S, Pena, I, Quesada-Campos, MT, Reid, IH, Revill, C, Riley, J, Ruiz-Gomez, JR, Shishikura, Y, Simeons, FRC, Smith, A, Smith, VC, Spinks, D, Stojanovski, L, Thomas, J, Thompson, S, Underwood, T, Gray, DW, Fiandor, JM, Gilbert, IH, Wyatt, PG, Read, KD & Miles, TJ 2019, ' Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis' Journal of Medicinal Chemistry, vol. 62, no. 3, pp. 1180-1202. https://doi.org/10.1021/acs.jmedchem.8b01218

Torrie, L, Zuccotto, F, Robinson, D, Gray, D, Gilbert, I & De Rycker, M 2019, 'Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase' PLoS ONE.

Tovell, H, Testa, A, Maniaci, C, Zhou, H, Prescott, A, Macartney, T, Ciulli, A & Alessi, D 2019, 'Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader' ACS Chemical Biology , vol. 14, no. 5, pp. 882-892. https://doi.org/10.1021/acschembio.8b01016

Trenaman, A, Glover, L, Hutchinson, S & Horn, D 2019, 'A post-transcriptional respiratome regulon in trypanosomes' Nucleic Acids Research. https://doi.org/10.1093/nar/gkz455

Velasco, RF, Guerrero, C, Fra, G, Moure, A, Miguel-Siles, J, Quesada-Campos, MT, Ruiz-Gomez, JR, Gilbert, IH, Thomas, MG & Miles, TJ 2019, 'Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound' Tetrahedron Letters, vol. 60, no. 18, pp. 1243-1247. https://doi.org/10.1016/j.tetlet.2019.03.068

Wyllie, S, Brand, S, Thomas, M, De Rycker, M, Chung, C-W, Peña, I, Bingham, R, Bueren-Calabuig, J, Cantizani, J, Cebrian, D, Craggs, PD, Ferguson, L, Goswami, P, Hobrath, J, Howe, J, Jeacock, L, Ko, EJ, Korczynska, J, MacLean, L, Manthri, S, Santos Martinez, M, Mata-Cantero, L, Moniz, S, Nuhs, A, Osuna-Cabello, M, Pinto, E, Riley, J, Robinson, S, Rowland, P, Simeons, F, Shishikura, Y, Spinks, D, Stojanovski, L, Thomas, J, Thompson, S, Viayna Gaza, E, Wall, R, Zuccotto, F, Horn, D, Ferguson, M, Fairlamb, A, Fiandor, JM, Martín, J, Gray, D, Miles, TJ, Gilbert, I, Read, K, Marco, M & Wyatt, P 2019, 'Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition' Proceedings of the National Academy of Sciences, vol. 116, no. 19, 201820175, pp. 9318-9323. https://doi.org/10.1073/pnas.1820175116, https://doi.org/10.1073/pnas.1820175116

EAT Study Team, Marrs, T, Logan, K, Craven, J, Radulovic, S, McLean, WHAI, Lack, G, Flohr, C & Perkin, MR 2019, ' Dog ownership at three months of age is associated with protection against food allergy' Allergy. https://doi.org/10.1111/all.13868