Date:
19 Jan 2012, 12:00 - 13:00

Ian Hickson studies various aspects of DNA repair and replication in yeast and human cells. He is famed for his seminal work on the cellular roles of the RecQ family of DNA helicases. His group discovered the protein defective in the human cancer predisposition disorder, Bloom’s syndrome, is the BLM DNA helicase, which plays vitally important roles in DNA replication and repair. Ian’s elegant biochemical work defined the mechanism by which this protein, BLM, acts to dissolve DNA structures such as 4-way (Holliday) junctions that accumulate during homologous recombination in human cells. Ian is also famed for his discovery a novel type of ultra-fine bridges (UFBs), DNA structures that arise at the anaphase of cell division from so-called common fragile sites in the genome. Ian has published over 150 research papers, many of which have been cited over 200 times, and he was recently elected a Fellow of the Royal Society (FRS). His talk will appeal to those interested in cell cycle, DNA metabolism, DNA repair and cancer.

Type of Event:
Seminar

Speaker:
Ian Hickson

Location:
MSI Small Lecture Theatre