University of Dundee

MRC Protein Phosphorylation Unit 2012

Al-Salihi, M. A., Herhaus, L. and Sapkota, G. P. (2012) Regulation of the transforming growth factor beta pathway by reversible ubiquitylation. Open Biol. 2, 120082
doi. 10.1098/rsob.120082
Pubmed. 22724073

Appleyard, M. V., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. and Thompson, A. M. (2012) Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer. 106, 1117-1122
doi. 10.1038/bjc.2012.56
Pubmed. 22361631

Bruce, D. L. and Sapkota, G. P. (2012) Phosphatases in SMAD regulation. FEBS Lett. 586, 1897-1905
doi. 10.1016/j.febslet.2012.02.001
Pubmed. 22576046

Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. and Rider, M. H. (2012) AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J. 443, 193-203
doi. 10.1042/BJ20112026
Pubmed. 22233421

Castaneda-Bueno, M., Cervantes-Perez, L. G., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. and Gamba, G. (2012) Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 109, 7929-7934
doi. 10.1073/pnas.1200947109
Pubmed. 22550170

Din, F. V., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, K., Alessi, D. R. and Dunlop, M. G. (2012) Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells. Gastroenterology. 142, 1504-1515 e1503
doi. 10.1053/j.gastro.2012.02.050
Pubmed. 22406476

Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C. and Chen, S. (2012) Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. Am J Physiol Endocrinol Metab. 302, E1036-1043
doi. 10.1152/ajpendo.00379.2011
Pubmed. 22318952

Dzamko, N., Inesta-Vaquera, F., Zhang, J., Xie, C., Cai, H., Arthur, S., Tan, L., Choi, H., Gray, N., Cohen, P., Pedrioli, P., Clark, K. and Alessi, D. R. (2012) The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling. PLoS One. 7, e39132
doi. 10.1371/journal.pone.0039132
Pubmed. 22723946

Goh, E. T., Arthur, J. S., Cheung, P. C., Akira, S., Toth, R. and Cohen, P. (2012) Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system. Biochem J. 441, 339-346
doi. 10.1042/BJ20111415
Pubmed. 22007846

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. and Hardie, D. G. (2012) The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 336, 918-922
doi. 10.1126/science.1215327
Pubmed. 22517326

Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. and Goransson, O. (2012) The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes. Biochem J. 444, 503-514
doi. 10.1042/BJ20111932
Pubmed. 22462548

Ho, K. K., McGuire, V. A., Koo, C. Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. and Lam, E. W. (2012) Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem. 287, 1545-1555
doi. 10.1074/jbc.M111.284224
Pubmed. 22128155

Joanne, P., Hourde, C., Ochala, J., Cauderan, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. and Ferry, A. (2012) Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle. PLoS One. 7, e35346
doi. 10.1371/journal.pone.0035346
Pubmed. 22511986

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., Knebel, A., Alessi, D. R. and Muqit, M. M. (2012) PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2, 120080
doi. 10.1098/rsob.120080
Pubmed. 22724072

Liu, Q., Kirubakaran, S., Hur, W., Niepel, M., Westover, K., Thoreen, C. C., Wang, J., Ni, J., Patricelli, M. P., Vogel, K., Riddle, S., Waller, D. L., Traynor, R., Sanda, T., Zhao, Z., Kang, S. A., Zhao, J., Look, A. T., Sorger, P. K., Sabatini, D. M. and Gray, N. S. (2012) Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 287, 9742-9752
doi. 10.1074/jbc.M111.304485
Pubmed. 22223645

Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. and Rena, G. (2012) Cellular responses to the metal-binding properties of metformin. Diabetes. 61, 1423-1433
doi. 10.2337/db11-0961
Pubmed. 22492524

Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. and Arthur, J. S. (2012) Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 441, 347-357
doi. 10.1042/BJ20110970
Pubmed. 21970321

Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. and van Aalten, D. M. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. Embo J. 31, 1394-1404
doi. 10.1038/emboj.2012.8
Pubmed. 22307082

Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. and Cohen, P. (2012) Essential Role for IKKbeta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells. J Biol Chem. 287, 19216-19228
doi. 10.1074/jbc.M112.345405
Pubmed. 22511786

Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. and Alessi, D. R. (2012) SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. Biochem J. 441, 325-337
doi. 10.1042/BJ20111879
Pubmed. 22032326

Tran, H. T., Nimick, M., Uhrig, R. G., Templeton, G., Morrice, N., Gourlay, R., Delong, A. and Moorhead, G. B. (2012) Arabidopsis thaliana histone deacetylase 14 (HDA14) is an alpha-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Plant Jdoi. 10.1111/j.1365-313X.2012.04984.x
Pubmed. 22404109

Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. and Gray, N. S. (2012) Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 22, 1864-1869
doi. 10.1016/j.bmcl.2012.01.084
Pubmed. 22335897

Wullschleger, S., Garcia-Martinez, J. M. and Duce, S. L. (2012) Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma. Anticancer Res. 32, 415-420
Pubmed. 22287727

Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. and Gray, N. S. (2012) Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 19, 140-154
doi. 10.1016/j.chembiol.2011.11.010
Pubmed. 22284361