University of Dundee

Medical Research Council Protein Phosphorylation Unit 2013

Alessi, D. R. and Kulathu, Y. (2013) Structural biology: Security measures of a master regulator. Nature. 497, 193-194
doi. 10.1038/nature12101,
Pubmed. 23636322,

Allen, G. F., Toth, R., James, J. and Ganley, I. G. (2013) Loss of iron triggers PINK1/Parkin-independent mitophagy. EMBO Rep. 14, 1127-1135
doi. 10.1038/embor.2013.168,
Pubmed. 24176932, PMC 3981094

Aregger, M. and Cowling, V. H. (2013) Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites. Biochem J. 455, 67-73
doi. 10.1042/BJ20130378,
Pubmed. 23863084, PMC 3778707

Beck, J., Maerki, S., Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J. R., Peter, M. and Sumara, I. (2013) Ubiquitylation-dependent localization of PLK1 in mitosis. Nat Cell Biol. 15, 430-439
doi. 10.1038/ncb2695,
Pubmed. 23455478,

Bett, J. S., Ibrahim, A. F., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. and Hay, R. T. (2013) The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem J. 451, 185-194
doi. 10.1042/BJ20130026,
Pubmed. 23398456, PMC 3632086

Cao, R., Butcher, G. Q., Karelina, K., Arthur, J. S. and Obrietan, K. (2013) Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock. Eur J Neurosci. 37, 130-140
doi. 10.1111/ejn.12028,
Pubmed. 23127194, PMC 3575747

Caster, D. J., Korte, E. A., Nanda, S., et al including Cohen, P. and Powell, D. W. (2013) ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis. J Am Soc Nephrol. 24, 1743-1754
doi. 10.1681/ASN.2013020148,
Pubmed. 23970121,

Castor, D., Nair, N., Declais, A. C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M., Arthur, J. S. and Rouse, J. (2013) Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell. 52, 221-233
doi. 10.1016/j.molcel.2013.08.036,
Pubmed. 24076219, PMC 3808987

Clark, K., Nanda, S. and Cohen, P. (2013) Molecular control of the NEMO family of ubiquitin-binding proteins. Nat Rev Mol Cell Biol. 14, 673-685
doi. 10.1038/nrm3644,
Pubmed. 23989959,

Cohen, P. and Alessi, D. R. (2013) Kinase Drug Discovery - What's Next in the Field? ACS Chem Biol. 8, 96-104
doi. 10.1021/cb300610s,
Pubmed. 23276252
PMC 4208300

Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B. and Melrose, H. L. (2013) Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. Biochem J. 453, 101-113
doi. 10.1042/BJ20121742,
Pubmed. 23560750, PMC 3682752

Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P. J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P. and Moechars, D. W. (2013) Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. J Pharm Biomed Anal. 76C, 49-58
doi. 10.1016/j.jpba.2012.12.002,
Pubmed. 23313773, PMC 4196644

Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J. D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S. and Gray, N. S. (2013) Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 70, 758-767
doi. 10.1016/j.ejmech.2013.10.052,
Pubmed. 24239623, PMC 3914206

Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F. and Schulman, B. A. (2013) Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Structure. 21, 1030-1041
doi. 10.1016/j.str.2013.04.019,
Pubmed. 23707686, PMC 3747818

Elcombe, S. E., Naqvi, S., Van Den Bosch, M. W., Mackenzie, K. F., Cianfanelli, F., Brown, G. D. and Arthur, J. S. (2013) Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers. PloS one. 8, e60086
doi. 10.1371/journal.pone.0060086,
Pubmed. 23533666, PMC 3606242

Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. and Knapp, S. (2013) X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor. J Med Chem. 56, 4413-4421
doi. 10.1021/jm4000837,
Pubmed. 23656407, PMC 3683888

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S., Pedrioli, P. G., Komander, D. and Cohen, P. (2013) Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A. 110, 15247-15252
doi. 10.1073/pnas.1314715110,
Pubmed. 23986494, PMC 3780889

Eser, S., et al including Alessi, D. R. and Saur, D. (2013) Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer. Cancer Cell. 23, 406-420
doi. 10.1016/j.ccr.2013.01.023,
Pubmed. 23453624,

Flinn, L. J., Keatinge, M., Bretaud, S., Mortiboys, H., Matsui, H., De Felice, E., Woodroof, H. I., Brown, L., McTighe, A., Soellner, R., Allen, C. E., Heath, P. R., Milo, M., Muqit, M. M., Reichert, A. S., Koster, R. W., Ingham, P. W. and Bandmann, O. (2013) TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Ann Neurol. 74, 837-847
doi. 10.1002/ana.23999,
Pubmed. 24027110, PMC 4154126

Fritsch, M. J., Trunk, K., Diniz, J. A., Guo, M., Trost, M. and Coulthurst, S. J. (2013) Proteomic identification of novel secreted antibacterial toxins of the Serratia marcescens type VI secretion system. Mol Cell Proteomics. 12, 2735-2749
doi. 10.1074/mcp.M113.030502,
Pubmed. 23842002, PMC 3790287

Ganley, I. G. (2013) Autophagosome maturation and lysosomal fusion. Essays Biochem. 55, 65-78
doi. 10.1042/bse0550065,
Pubmed. 24070472,

Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. and Tauro, S. (2013) p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia. Br J Cancer. 109, 2434-2344
doi. 10.1038/bjc.2013.601,
Pubmed. 24091621, PMC 3817336

Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M., Agnew, B. and Kuster, B. (2013) Proteome Wide Purification and Identification of O-GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry. J Proteome Res. 12, 927-636
doi. 10.1021/pr300967y,
Pubmed. 23301498

Hardie, D. G. and Alessi, D. R. (2013) LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol. 11, 36
doi. 10.1186/1741-7007-11-36,
Pubmed. 23587167, PMC 3626889

Hau, A. M., Greenwood, J. A., Lohr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., McPhail, K. L. and Ishmael, J. E. (2013) Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells. PloS one. 8, e65250
doi. 10.1371/journal.pone.0065250,
Pubmed. 23762328, PMC 3675158

Herhaus, L., Al-Salihi, M., Macartney, T., Weidlich, S. and Sapkota, G. P. (2013) OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nat Commun. 4, 2519
doi. 10.1038/ncomms3519,
Pubmed. 24071738, PMC 3791481

Hoxhaj, G., Dissanayake, K. and Mackintosh, C. (2013) Effect of IRS4 Levels on PI 3-Kinase Signalling. PLoS One. 8, e73327
doi. 10.1371/journal.pone.0073327,
Pubmed. 24039912, PMC 3769281

Jeppesen, J., Maarbjerg, S. J., Jordy, A. B., Fritzen, A. M., Pehmoller, C., Sylow, L., Serup, A. K., Jessen, N., Thorsen, K., Prats, C., Qvortrup, K., Dyck, J. R., Hunter, R. W., Sakamoto, K., Thomson, D. M., Schjerling, P., Wojtaszewski, J. F., Richter, E. A. and Kiens, B. (2013) LKB1 regulates lipid oxidation during exercise independently of AMPK. Diabetes. 62, 1490-1499
doi. 10.2337/db12-1160,
Pubmed. 23349504, PMC 3636614

Kelsall, I. R., Duda, D. M., Olszewski, J. L., Hofmann, K., Knebel, A., Langevin, F., Wood, N., Wightman, M., Schulman, B. A. and Alpi, A. F. (2013) TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. Embo J. 32, 2848-2860
doi. 10.1038/emboj.2013.209,
Pubmed. 24076655, PMC 3817463

Krishnan, N., Bencze, G., Cohen, P. and Tonks, N. K. (2013) The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases. Febs J. 280, 2830-2841
doi. 10.1111/febs.12283,
Pubmed. 23578302, PMC 3712534

Lee, H., Alpi, A. F., Park, M. S., Rose, A. and Koo, H. S. (2013) C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog. PloS one. 8, e60071
doi. 10.1371/journal.pone.0060071,
Pubmed. 23555887, PMC 3610817

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. and Tauro, S. (2013) Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 3, 1275
doi. 10.1038/srep01275,
Pubmed. 23429453, PMC 3572444

MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Noehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G., Barton, G. J., Toth, R., Prescott, A. and Arthur, J. S. (2013) PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol. 190, 565-577
doi. 10.4049/jimmunol.1202462,
Pubmed. 23241891, PMC 3620524

MacKenzie, K. F., Van Den Bosch, M. W., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. and Arthur, J. S. (2013) MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Mol Cell Biol. 33, 1456-1467
doi. 10.1128/MCB.01690-12,
Pubmed. 23382072, PMC 3624268

Mariappa, D., Pathak, S. and van Aalten, D. M. (2013) A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription. Embo J. 32, 612-613
doi. 10.1038/emboj.2013.26,
Pubmed. 23403924, PMC 3590992

McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L., O'Keefe, S. J., Boothby, M., Gaestel, M. and Arthur, J. S. (2013) Cross talk between the Akt and p38alpha pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol. 33, 4152-4165
doi. 10.1128/MCB.01691-12,
Pubmed. 23979601, PMC 3811899

Mehellou, Y., Alessi, D. R., Macartney, T. J., Szklarz, M., Knapp, S. and Elkins, J. M. (2013) Structural insights into the activation of MST3 by MO25. Biochem Biophys Res Commun. 431, 604-609
doi. 10.1016/j.bbrc.2012.12.113,
Pubmed. 23296203, PMC 3725419

Melo, Z., de los Heros, P., Cruz-Rangel, S., Vazquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A. and Gamba, G. (2013) N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling. J Biol Chem. 288, 31468-31476
doi. 10.1074/jbc.M113.475574,
Pubmed. 24043619, PMC 3814743

Moore, S. F., van den Bosch, M. T., Hunter, R. W., Sakamoto, K., Poole, A. W. and Hers, I. (2013) Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt Promotes Thrombin-mediated Integrin alphaIIbbeta3 Activation and Granule Secretion in Platelets. J Biol Chem. 288, 3918-3928
doi. 10.1074/jbc.M112.429936,
Pubmed. 23239877, PMC 3567645

Ohta, A., Schumacher, F. R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. and Kurz, T. (2013) The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J. 451, 111-122
doi. 10.1042/BJ20121903,
Pubmed. 23387299, PMC 3632089

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. and Cohen, P. (2013) DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA. J Biol Chem. 288, 24569-24580
doi. 10.1074/jbc.M113.479550,
Pubmed. 23846693, PMC 3750155

Park, J., Al-Ramahi, I., Tan, Q., Mollema, N., Diaz-Garcia, J. R., Gallego-Flores, T., Lu, H. C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L. S., Richman, R., Liu, X., Gao, Y., Shaw, C. A., Arthur, J. S., Orr, H. T., Westbrook, T. F., Botas, J. and Zoghbi, H. Y. (2013) RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 498, 325-331
doi. 10.1038/nature12204,
Pubmed. 23719381, PMC 4020154

Pattison, M. J., Mackenzie, K. F., Elcombe, S. E. and Arthur, J. S. (2013) IFNbeta autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages. FEBS letters. 587, 1496-1503
doi. 10.1016/j.febslet.2013.03.025,
Pubmed. 23542035, PMC 3655261

Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S. and Cohen, P. (2013) Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. J Immunol. 191, 2717-2730
doi. 10.4049/jimmunol.1203268,
Pubmed. 23918981, PMC 3849919

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. and Cantrell, D. A. (2013) The Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells. PloS one. 8, e77537
doi. 10.1371/journal.pone.0077537,
Pubmed. 24155966, PMC 3796494

Remenyi, J., van den Bosch, M. W., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S., Frenguelli, B. G. and Pankratov, Y. (2013) miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity. PloS one. 8, e62509
doi. 10.1371/journal.pone.0062509,
Pubmed. 23658634, PMC 3637221

Rezgui, V. A., Tyagi, K., Ranjan, N., Konevega, A. L., Mittelstaet, J., Rodnina, M. V., Peter, M. and Pedrioli, P. G. (2013) tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding. Proc Natl Acad Sci U S A. 110, 12289-12294
doi. 10.1073/pnas.1300781110,
Pubmed. 23836657, PMC 3725067

Ritorto, M. S., Cook, K., Tyagi, K., Pedrioli, P. G. and Trost, M. (2013) Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes. J Proteome Res. 12, 2449-2457
doi. 10.1021/pr301011r,
Pubmed. 23294059, PMC 3679572

Ritorto, M. S., Trost, M. and Cook, K. (2013) Hydrophilic strong anion exchange chromatography for proteomics: what's the future outlook? Bioanalysis. 5, 2219-2221
doi. 10.4155/bio.13.205,
Pubmed. 24053235

Sapkota, G. P. (2013) The TGFbeta-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1. Open Biol. 3, 130067
doi. 10.1098/rsob.130067,
Pubmed. 23760366, PMC 3718330

Sommer, E. M., Dry, H., Cross, D., Guichard, S., Davies, B. R. and Alessi, D. R. (2013) Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. Biochem J. 452, 499-508
doi. 10.1042/BJ20130342,
Pubmed. 23581296, PMC 3671793

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. and Cohen, P. (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 451, 427-437
doi. 10.1042/BJ20121651,
Pubmed. 23441730, PMC 3685219

Venigalla, R. K., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. and Arthur, J. S. (2013) PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. Embo J. 32, 1008-1022
doi. 10.1038/emboj.2013.40,
Pubmed. 23463102, PMC 3616287

Voelkl, J., Mia, S., Meissner, A., Ahmed, M. S., Feger, M., Elvira, B., Walker, B., Alessi, D. R., Alesutan, I. and Lang, F. (2013) PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction. Kidney Blood Press Res. 38, 156-164
doi. 10.1159/000355763,
Pubmed. 24685987

von Wilamowitz-Moellendorff, A., Hunter, R. W., Garcia-Rocha, M., Kang, L., Lopez-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martinez-Pons, C., Voss, M., Calbo, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. and Sakamoto, K. (2013) Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 62, 4070-4082
doi. 10.2337/db13-0880,
Pubmed. 23990365, PMC 3837029

Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. and Cohen, P. T. W. (2013) Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with gamma-tubulin. Cell cycle. 12, 2876-2887
doi. 10.4161/cc.25919,
Pubmed. 23966160, PMC 3899200

Wan, M., Leavens, K. F., Hunter, R. W., Koren, S., von Wilamowitz-Moellendorff, A., Lu, M., Satapati, S., Chu, Q., Sakamoto, K., Burgess, S. C. and Birnbaum, M. J. (2013) A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell Metab. 18, 99-105
doi. 10.1016/j.cmet.2013.06.001,
Pubmed. 23823480, PMC 3725134

Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., Mackintosh, C. and Chen, S. (2013) AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 449, 479-489
doi. 10.1042/BJ20120702,
Pubmed. 23078342, PMC 3685216

Wilson, J. S., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. and Rouse, J. (2013) Localization-dependent and -independent roles of SLX4 in regulating telomeres. Cell Rep. 4, 853-860
doi. 10.1016/j.celrep.2013.07.033,
Pubmed. 23994477, PMC 3969258

Wong, P. M., Puente, C., Ganley, I. G. and Jiang, X. (2013) The ULK1 complex: Sensing nutrient signals for autophagy activation. Autophagy. 9, 124-137
doi. 10.4161/auto.23323,
Pubmed. 23295650, PMC 3552878

Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. and Chen, S. G. (2013) Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum Mol Genet. 22, 328-344
doi. 10.1093/hmg/dds431,
Pubmed. 23065705, PMC 3526163

Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. and Kurz, T. (2013) CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Nat Commun. 4, 1641
doi. 10.1038/ncomms2628,
Pubmed. 23535662