The genomes of eukaryotes are organised as chromatin. This means that any process that requires access to DNA must contend with chromatin. This means that regulating chromatin structure is fundamental to many biological systems. In addition, it has recently become apparent that defects in chromatin organisation are associated with a wide range of human diseases including cancer. We are interested in learning how chromatin is regulated so as to allow genetic process such as transcription and DNA replication to occur at the right time and place. To do this we use a diverse range of experimental approaches that include genomics, high performance microscopy, and structural biology. A range of projects are available and input from applicants in constructing research projects is encouraged.
- Narlikar GJ, Sundaramoorthy R, Owen-Hughes T. Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes. Cell. 2013 Aug 1;154(3):490-503. doi: 10.1016/j.cell.2013.07.011. PubMed PMID: 23911317