Deciphering how disruptions in phosphorylation and ubiquitin networks lead to disease will reveal novel drug targets and improved strategies to treat these maladies in the future. Recent research has highlighted an exquisite interplay between phosphorylation and ubiquitin pathways that regulate many physiological systems. This includes pathways of relevance to understanding innate immunity, Parkinson's disease and cancer. Central questions being addressed by the research groups in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) include understanding how ubiquitin and phosphorylation pathways are organised, characterising the interplay between these pathways, determining how they recognise and respond to signals, and uncovering how disruption of these networks causes disease.
The MRC Protein Phosphorylation and Ubiquitylation Unit (MRCPPU) is based in the College of Life Sciences. The MRC PPU PhD programme provides research training to candidates with an outstanding academic record and strong interest in carrying out research on the roles of protein phosphorylation in cell regulation and human disease. Although the Unit operates its own PhD programme its students are registered with the University of Dundee. Two types of PhD are offered: 3.5 yr studentship where students work in one lab only, or a 4 yr studentship, which involves rotations in two MRC PPU labs in the first year. Details can be found at the MRC Prize Studentship website.
The key elements of the programme consist of:
- PhD projects in laboratories run by internationally renowned scientists
- Structured training and mentoring programme
- Competitive stipend of £17,500 per annum, tuition fees, relocation allowance and £2000 towards attendance at conferences and training courses.
- Interaction with internationally renowned pharmaceutical companies
For further information and how to apply for this programme please see the MRC Prize Studentship website.