The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:
- Cellular Regulation
- Protein Modification
- Infection and Immunity
- Drug Discovery and Translation
Around 50 different potential supervisors will participate in this programme
Prof Alessio Ciulli
Research from us and others over the past decade have contributed to the advent of a new modality of chemical and drug intervention to study biology and cure disease. Instead of blocking a target protein as conventionally done with inhibitors, we are designing “tailored” bifunctional molecules that bring a target protein to an E3 ubiquitin ligase. We are beginning to understand the rules and principles of how to design and study this new class of molecules and how to best investigate the profound biological consequences and attractive therapeutic potential of targeted protein degradation. Our research in this area takes a multidisciplinary approach including organic and medicinal chemistry and computational tools to design and achieve desired molecules; structural biology and biophysics to study binary and ternary complexes in solution and reveal their structural and dynamic interactions; and chemical biology, biochemistry, proteomics and cell biology to study the cellular impact of our small molecules into relevant cellular systems – for example cancer cells sensitive to the knockdown of the protein target in question, or model cell lines suitable for biological investigation of specific signalling pathways.