Protein degradation is a fundamental process in cells that is important for timely elimination of damaged proteins. This process relies on modification of proteins with ubiquitin, a signal to target destruction of modified proteins via the proteasome. Failure to eliminate damaged/misfolded proteins is an underlying cause of age-related diseases such as Alzheimer’s and Parkinson’s disease. Excitingly, we have recently discovered a new family of proteins that regulate protein degradation signals. The aim of this project is to decipher how protein homeostasis is regulated by these newly identified players. In your PhD, you will employ a range of techniques including biochemical approaches, state-of-the-art ubiquitin proteomics, mouse models and CRISPR/Cas9 genome-editing methods to elucidate new layers of control in protein degradation, research that will advance our understanding of neurodegenerative diseases.