Our group is interested in uncovering mechanisms that control the capacity of Embryonic Stem (ES) cells to self-renew or differentiate into specialized lineages and tissues. Although the transcriptional mechanisms that underpin this process are increasingly understood, very little is known about the role of signaling pathways and networks. Our current focus is on applying cutting-edge proteomic and small molecule inhibitor technologies together with high-throughout functional approaches to elucidate and characterize novel protein phosphorylation networks in ES cells. The ultimate goal of my lab is to identify protein kinase targets and inhibitors that can be exploited to synthetically manipulate ES cells in the laboratory. In this project, the successful applicant will have an exciting opportunity to study the fundamental mechanisms that underpin ES cell identity.
This work will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), one of the world’s leading centres studying the role of protein phosphorylation in health and disease. As well as a world-class research infrastructure and environment, students within the MRC-PPU benefit from a unique collaboration with six major Pharmaceutical companies supporting the Division of Signal Transduction Therapy. The MRC-PPU is located within the College of Life Sciences at the University of Dundee, and is situated in a beautiful location overlooking the estuary of the River Tay.