University of Dundee

Microbiology

China Scholarship Council: Phosphorylation of Rab GTPases in Health & Disease

Our lab investigates the function the PINK1 kinase which is mutated in Parkinson’s disease and is a master-regulator of mitophagy. Our lab has recently found a link between the Parkinson’s associated protein kinase PINK1 and a subset of Rab GTPases. PINK1 phosphorylates Rabs at a highly conserved Serine111 residue within the SF3 subdomain. The project will investigate the role of this phosphorylation site and this project will employ state-of-the-art methods to uncover the regulation of Rabs by PINK1 in cells.