University of Dundee

Computational Biology

EASTBIO: Regulation of mRNA capping in embryonic stem cells

Embryonic stem cells are pluripotent cells derived from early embryos that retain the ability to differentiate into all somatic cells.  Pluripotency is dependent on the expression of key pluripotency regulators.  On receiving signals to differentiate, gene expression profiles are reshaped to repress pluripotency factors and to express the proteins required of the new cell lineage.  Our focus is on understanding how cellular signalling pathways regulate the mRNA cap, a structure added to transcripts which is critical for gene expression.   The student will investigate how cellular signalling

EASTBIO CASE: Analysis of protein targets of small molecule splicing modulators

In human cells, almost every gene contains one or more introns that must be removed to generate mRNA. Alternative splicing refers to removing different combinations of introns, thereby generating multiple mRNAs, coding for proteins with different structures, from a single gene. Alternative splicing can generate different protein isoforms, which vary in function, substrate specificity and/or subcellular localisation.

China Scholarship Council PhD programme - Investigating the epigenetic basis of preleukaemic stem and progenitor cells in leukemogenesis

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Regulation of RNA cap is embryonic stem cell differentiation

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology

Recruitment for our Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology is now open.  Greater than 40 different supervisors participate with diverse research areas.  Further information can be found on the programme website.  Students on this programme will carry out three short laboratory placements prior to selection of main PhD project.

Deadline for applications set as 10th January 2020