University of Dundee

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A candidate-gene approach for targeted identification of new parasite immunomodulators against allergic asthma.(Supervisors: Dr Henry McSorley (University of Dundee) and Dr Hermelijn Smits (Leiden University Medical Centre, the Netherlands)

This project will build on our knowledge of how parasitic helminths manipulate the host immune response, in a collaboration between the groups of Dr Henry McSorley (University of Dundee) and Dr Hermelijn Smits (Leiden University Medical Centre, the Netherlands). The successful candidate for this 4 year PhD position will spend significant time in both Dundee and Leiden, to identify, characterise and translate their findings.

Developing innovative chemistry methodology to efficiently synthesise novel heterocycles as fragments.

Prof Paul Wyatt. Head of the Drug Discovery Unit, and Director of the Wellcome Centre for Anti-Infectives Research, University of Dundee is seeking a highly motivated and enthusiastic synthetic organic or medicinal chemist to carry out a PhD focused on developing innovative chemistry methodology to efficiently synthesise novel heterocycles as fragments. Fragments are low molecular weight and low complexity organic molecules suitable for initiating drug discovery projects.

The Impact of Scottish National Stewardship on E. coli Resistance and Admissions with Infection

A key approach to tackling antimicrobial resistance (AMR) is through improving the way we use antibiotics. The Scottish Antimicrobial Prescribing Group has guided improvements in antibiotic prescribing since 2008, with resulting changes in the community and in hospital. The impact of these changes on AMR and other potential adverse effects requires further evaluation. The aim is to investigate the impact of changes in antibiotic prescribing across Scotland on resistance among E.

Comparison of Antimicrobial Stewardship Programmes and Impact on Primary Care Prescribing in Scotland and England

Interventions to reduce antibiotic prescribing, with the aim of reducing antimicrobial resistance (AMR), have been implemented across the UK as part of antimicrobial stewardship programmes (ASPs). There are differences between NHS Scotland and NHS England in the design and implementation of ASPs, such as financial incentives in England. The aim is to describe these differences in detail, and quantify the impact of ASPs and their key components on antibiotic prescribing in primary care in each setting.

Characterising Antimicrobial Resistance in Care Homes using Whole Genome Sequencing

Antimicrobial resistance (AMR) is an increasing public health threat and it is important to understand the role of different factors contributing to AMR in individuals. Older people living in care homes are at higher than average risk of AMR infections and have high rates of antibiotic prescriptions and hospital admissions, and the risk of acquiring infections from other residents.

Mechanisms of intracellular transport in trypanosomes

A project to study the molecular mechanisms, functions and evolution of membrane transport in the African trypanosome is offered in the laboratory of Prof Mark Field. The work will investigate in detail the roles of a family of proteins recently identified as interacting with clathrin, the major endocytic coat protein, and which appear to be features specific to trypanosomes. Data will have relevance to parasitology, molecular evolution and the search for therapeutic targets. The project will involve state of the art proteomics, high resolution imaging and genetics/molecular biology.