University of Dundee

Professor Tomo Tanaka FRSE

Mechanisms ensuring proper chromosome segregation in mitosis
Position: 
Professor of Cell and Molecular Biology, Wellcome Trust Principal Research Fellow
Address: 
School of Life Sciences, University of Dundee, Dundee
Full Telephone: 
+44 (0) 1382 385814, int ext 85814
Email: 

Research

Teaching

A)  Lectures and tutorials for undergraduate students about chromosome segregation in mitosis
Level 3 (BS31006 Gene Regulation and Expression)
Level 4 (BS42010 Advanced Gene Regulation and Expression)
B) Supervisor of Honours degree students
C) Supervisor of PhD students
D) Coordinator of PhD student induction program

Publications

Major publications from the group

Li S, Yue Z & Tanaka TU. Smc3 deacetylation by Hos1 facilitates efficient dissolution of sister chromatid cohesion during early anaphase. Mol Cell. 68, 605-14 (2017) view paper

Yue, Z., Komoto, S. Gierlinski, M., Pasquali, D., Kitamura, E and Tanaka, T.U. (2017) Mechanisms mitigating problems associated with multiple kinetochores on one microtubule in early mitosis.    J. Cell. Sci. 130, 2266-2276. PMID:28546446; DOI 10.1242/jcs.203000.   view paper

Vasileva, V., Gierlinkski, M., Yue, Z., O'Reilly, N., Kitamura, E. and Tanaka, T.U. (2017) Molecular mechanisms facilitating the initital kinetochore encounter with spindle microtubules.  J.  Cell Biol., 216, 1609-22.   doi: 10.1083/jcb.201608122; PMID:28446512.  view paper

Kalantzaki, M., Kitamura, E., Zhang, T., Mino, A., Novák, B. and Tanaka, T. U. (2015) Kinetochore-microtubule error correction is driven by differentially regulated interaction modes. Nature Cell Biology, 17, 421-433.
doi; 10.1038/ncb.3128.; PMID: 25751138 View Paper

Kobayashi, N., Suzuki, Y., Schoenfeld, L. W., Müller, C. A., Nieduszynski, C., Wolfe, K. H. and Tanaka, T. U. (2015) Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres. Curr Biol 25; 2026-33.  doi; 10.1016/j.cub.2015.06.023; PMID: 26166782 View Paper

Tanaka, T.U., Clayton, L., Natsume, T. (2013) Three wise centromere functions: see no error, hear no break, speak no delay. EMBO Rep, 14, 1073-83.  doi; 10.1038/embor.2013.181. PMID: 24232185 View Paper

Natsume, T., Müller, C. A., Katou, Y., Retkute, R., Gierlinski, M., Araki, H., Blow, J. J., Shirahige, K., Nieduszynski, C. A. and Tanaka, T. U. (2013) Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell, 50, 661-74. (2013). doi; 10.1016/j.molcel.2013.05.011; PMID: 23746350 View Paper

Saner, N., Karschau, J., Natsume, T., Gierlinski, M.,  Retkute, R., Hawkins, M., Nieduszynski, C. A., Blow, J. J, de Moura,  A. P. S. and Tanaka, T. U. (2013) Stochastic association of neighboring replicons creates replication factories in budding yeast. J Cell Biol, 202, 1001-12. doi; 10.1083/jcb.201306143; PMCID: PMC3787376 View Paper

Gandhi, S. R, Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. and Tanaka, T. U. (2011) Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis. Dev Cell, 21, 920-33. doi; 10.1016/j.devcel.2011.09.006.; PMID: 22075150 View Paper

Maure, J-F.*, Komoto, S.*, Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. and Tanaka, T. U. (2011) The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Curr Biol, 21, 207-13. (* equal contribution) doi; 10.1016/j.cub.2010.12.050.; PMID: 21256019 View Paper

Kitamura, E.*, Tanaka, K.*, Komoto, S.*, Kitamura, Y., Antony, C. and Tanaka, T. U. (2010) Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Dev Cell, 18, 248-59. (* equal contribution) doi; 10.1016/j.devcel.2009.12.018.; PMID: 20159595 View Paper

Renshaw, M. J., Ward, J. J., Kanemaki, M., Natsume, K., Nedelec, F. J. and Tanaka, T. U. (2010) Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation. Dev Cell, 19, 232-44. doi; 10.1016/j.devcel.2010.07.013.; PMID: 20708586 View Paper

Tanaka, T. U. (2010) Kinetochore-microtubule interactions: steps towards bi-orientation. Embo J, 29, 4070-82. doi; 10.1038/emboj.2010.294; PMID: 21102558 View Paper

Kitamura, E., Tanaka, K., Kitamura, Y. and Tanaka, T. U. (2007) Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev, 21, 3319-30.
doi; 10.1101/gad.449407; PMID: 18079178  View Paper

Maure, J-F., Kitamura, E. and Tanaka, T. U. (2007) Mps1 kinase promotes sister kinetochore bi-orientation by a tension-dependent mechanism. Curr Biol, 17, 2175-82.
doi; 10.1016/j.cub.2007.11.032; PMID: 18060784; View Paper

Tanaka, K., Kitamura, E., Kitamura, Y. and Tanaka, T. U. (2007) Molecular mechanisms of microtubule-dependent kinetochore transport towards spindle poles. J Cell Biol, 178, 269-81.
doi; 10.1083/jcb.200702141; PMID: 17620411 View Paper

Kitamura, E., Blow J. J. and Tanaka, T. U. (2006) Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell, 125, 1297-308.
doi; 10.1016/j.cell.2006.04.041; PMID: 16814716 View Paper

Tanaka, K., Mukae, N., Dewar, H., van Breugel, M., James, E. K., Prescott, A. R., Antony, C. and Tanaka T. U. (2005) Molecular mechanisms of kinetochore capture by spindle microtubules.  Nature 434, 987-94. 
doi; 10.1038/nature03483; PMID: 15846338 View Paper

Dewar, H., Tanaka, K., Nasmyth, K. and Tanaka, T. U. (2004) Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature 428, 93-97.  PMID: 14961024 View Paper

Full Publications List

Impact

Errors in chromosome duplication or segregation generate cells with missing or excessive chromosomes (aneuploidy). Aneuploidy could cause various human diseases such as cancers and congenital disorders. It is therefore crucial to understand the molecular mechanisms ensuring proper chromosome duplication and segregation.