University of Dundee

Dr Paul Campbell

The application of Physics to Biology
Position: 
Associate Principal Investigator
Address: 
College of Life Sciences, University of Dundee, Dundee
Full Telephone: 
+44 (0) 1382 384404, int ext 84804
Email: 

Research

Dr Campbell heads up a multi-disciplinary team of physicists and engineers working at the interface with life sciences and medicine. Our goal is to produce creative technological solutions to the outstanding biomedical challenges of our time. To that end, we proactively develop strategic, physics-driven concepts, that are convergent with emerging biotechnologies. Our present focus seeks to exploit the power of ultrasound for non-invasive drug delivery and includes projects on:

Nucleic Acid Delivery: Understanding, and optimising, the delivery of siRNA to counter skin dysfunction.

Cavitation Physics: Investigating the complexity of interactions that arise during inertial cavitation so that future bubble-therapies can be optimised.

Engineered Microbubbles: For use as generic targeting vectors carrying a range of molecular payloads.

Covert Biometrics: Investigating human-technology interfaces, specifically touchscreens, as an automated non-intrusive means of user identification and authentication.

Societal portrayals of Physics and Physicists: Understanding the societal contexts leading to science perception in the lay population, and also as a mean of verifying and elucidating historical data and information.

Dr Campbell actively collaborates with several eminent international researchers in Japan, Singapore and the USA.

Teaching

At present, Dr Campbell is formally on secondment to Ionscope Ltd in Cambridge as part of a Royal Society Industry Fellowship, and will be working almost exclusively on research until August 2014. Previously he has developed and delivered the following modules within the Physics Division:

EG12001: Electricity Optics & Waves
EE32002: Solid State Physics
PH31001: Electricity and Magnetism
PH12003: Space Physics and Astronomical Phenomena

He is delivering PH12003 (Semester 2: Jan 2014) and PH31001 (Semester 1: Sept 2014) this present academic year.

Publications

In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

Vikas Hegde, Robyn P. Hickerson, Sitheswaran Nainamalai, Paul A. Campbell, Frances J.D. Smith, W. H. Irwin McLean, Deena M. Leslie Pedrioli

Journal of Controlled Release 196, 355-362 (2014)

 

DNA double strand breaks induced by cavitational mechanical effects of ultrasound in cancer cells

Y Furusawa, Y Fujiwara, P Campbell, QL Zhao, R Ogawa, MA Hassan, Y Tabuchi, I Takasaki, A Takahashi &, T Kondo

PloS One (2012) 7 (1) e29012 (2012)

 

Enhanced gene transfection using calcium phosphate co-precipitates and low-intensity pulsed ultrasound

MA Hassan, I.S. Ahmed, PA Campbell & T Kondo

European Journal of Pharmaceutical Sciences 47(4): 768-773 (2012)

 

What lies beneath?

MJ Conneely & PA Campbell

Journal of Investigative Dermatology 133, 1458-1460 (2013)

 

Spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector

T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

Hwee San Lek, Vicky L Morrison, Michael Conneely, Paul A Campbell, David McGloin, Alan Prescott, Susanna C Fagerholm

Journal of Biological Chemistry 288 (21), 14698-14708 (2013)

 

Keystroke Dynamics in the pre-Touchscreen Era

Nasir Ahmad, Andrea Szymkowiak & Paul A. Campbell

Frontiers in Neuroscience 7: 835 (2013) doi: 10.3389/fnhum.2013.00835

 

Curious Warriors: The Portrayal of Physicists in Comics

PA Campbell

MLitt thesis, University of Dundee (2013)

 

Jitter reduction using native fiducials in rotating mirror ultra-fast microphotography

BHT Goh, BC Khoo, WHI Mclean & PA Campbell

Optics Express 22 (13) 16282 (2014)