University of Dundee

Professor Kate Storey FRSE

Neural differentiation in embryos and embryonic stem cells
Position: 
Professor of Neural Development and Head of the Division of Cell and Developmental Biology
Address: 
School of Life Sciences, University of Dundee, Dundee
Full Telephone: 
+44 (0) 1382 385691, int ext 85691
Email: 

Research

Cell division in the neural tube

We wish to understand how neural cells arise and how their proliferation and differentiation are controlled. Our work focuses on the developing spinal cord and insights from these studies inform our investigation of these processes in embryonic stem cell derived neural tissue and in maturing spinal cord progenitors, which become adult neural stem cells. We address these questions using cell specific gain and loss of gene function approaches as well as genome-wide analyses and real-time imaging techniques. The overall aim of our work is to identify the gene regulatory mechanisms that control neural differentiation, with a long-term goal to inform strategies for therapeutic treatment of neural injury and disease.

Teaching

Contributes lectures to:

 

Human Embryology and Morphology – year 4

Stem Cells in Development and Disease – year 4

Cell & Developmental Biology – year 3​

 

and suprevision for:

Honours student projects – x2 10-week projects

Graduate student seminars/rotation projects – year 1

Publications

Verrier, L. Davidson, L. Gierliński, M. Storey, K.G. (2016) Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro
doi: 10.1101/182279

Rodrigo Albors, A, Halley, P.A. Storey, K.G. Fate mapping caudal lateral epiblast reveals continuous contribution to neural and mesodermal lineages and the origin of secondary neural tube
doi: 10.1101/045872

Henrique, D., Abranches, E., Verrier, L. and Storey, K. G. (2015) Neuromesodermal progenitors and the making of the spinal cord. Development. 142, 2864-2875
d.o.i 10.1242/dev.119768
P.M.C.I.D PMID 26329597

Olivera-Martinez, I., Schurch, N., Li, R. A., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. and Storey, K. G. (2014) Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development. 141, 3266-3276
d.o.i 10.1242/dev.112623
P.M.C.I.D 4197544
PMID 25063452

Das, R. M. and Storey, K. G. (2014) Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science. 343, 200-204
d.o.i 10.1126/science.1247521
P.M.C.I.D 4066580
PMID 24408437

Patel, N. S., Rhinn, M., Semprich, C. I., Halley, P. A., Dolle, P., Bickmore, W. A. and Storey, K. G. (2013) FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS genetics. 9, e1003614
d.o.i 10.1371/journal.pgen.1003614
P.M.C.I.D 3715432
PMID 23874217

Olivera-Martinez, I., Harada, H., Halley, P. A. and Storey, K. G. (2012) Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. PLoS biology. 10, e1001415
d.o.i 10.1371/journal.pbio.1001415
P.M.C.I.D 3484059
PMID 23118616

Das, R. M. and Storey, K. G. (2012) Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube. EMBO reports. 13, 448-454
d.o.i 10.1038/embor.2012.42
P.M.C.I.D 3343353
PMID 22491029

Das, R. M., Wilcock, A. C., Swedlow, J. R. and Storey, K. G. (2012) High-resolution live imaging of cell behavior in the developing neuroepithelium. Journal of visualized experiments : JoVEd.o.i 10.3791/3920
P.M.C.I.D 3466664
PMID 22525126