University of Dundee

Professor Colin Watts FRS FRSE FMedSci

The Cell Biology of the Immune System
Position: 
Professor of Immunobiology
Address: 
School of Life Sciences, University of Dundee, Dundee
Full Telephone: 
+44 (0) 1382 384233, int ext 84233
Email: 

Publications

Freeley, S, Cardone, J, Günther, SC, West, EE, Reinheckel, T, Watts, C, Kemper, C & Kolev, MV 2018, 'Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation' Frontiers in Immunology, vol. 9, 2449, pp. 1-7. https://doi.org/10.3389/fimmu.2018.02449

Martinez-Fabregas, J, Prescott, A, van Kasteren, S, Leslie Pedrioli, D, McLean, W, Moles, A, Reinheckel, T, Poli, V & Watts, C 2018, 'Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis' Nature Communications, vol. 9, no. 1, 5343, pp. 1-16. https://doi.org/10.1038/s41467-018-07741-6

Stathopoulou, C, Gangaplara, A, Mallett, G, Flomerfelt, FA, Liniany, LP, Knight, D, Samsel, LA, Berlinguer-Palmini, R, Yim, JJ, Felizardo, TC, Eckhaus, MA, Edgington-Mitchell, L, Martinez-Fabregas, J, Zhu, J, Fowler, DH, van Kasteren, SI, Laurence, A, Bogyo, M, Watts, C, Shevach, EM & Amarnath, S 2018, 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells' Immunity, vol. 49, no. 2, pp. 247-263.e7. https://doi.org/10.1016/j.immuni.2018.05.006

Matthews, SP, McMillan, SJ, Colbert, JD, Lawrence, RA & Watts, C 2016, 'Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis' Immunity, vol. 44, no. 4, pp. 795-806. https://doi.org/10.1016/j.immuni.2016.03.003

Zaru, R, Edgar, AJ, Hanauer, A & Watts, C 2015, 'Structural and functional basis for p38-MK2 activated Rsk signalling in Toll-Like receptor-stimulated dendritic cells' Molecular and Cellular Biology, vol. 35, no. 1, pp. 132-140. https://doi.org/10.1128/MCB.00773-14

Zaru, R, Matthews, SP, Edgar, AJ, Prescott, AR, Gomez-Nicola, D, Hanauer, A & Watts, C 2015, 'The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning' Journal of Immunology, vol. 195, no. 9, pp. 4264-4272. https://doi.org/10.4049/jimmunol.1501520

Gawden-Bone, C, West, MA, Morrison, VL, Edgar, AJ, McMillan, SJ, Dill, BD, Trost, M, Prescott, A, Fagerholm, SC & Watts, C 2014, 'A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells' Journal of Cell Science, vol. 127, no. 19, pp. 4213-4224. https://doi.org/10.1242/jcs.151167

Maher, K, Konjar, S, Watts, C, Turk, B & Kopitar-Jerala, N 2014, 'Cystatin F regulates proteinase activity in IL-2-activated natural killer cells' Protein and Peptide Letters, vol. 21, no. 9, pp. 957-965. https://doi.org/10.2174/0929866521666140403124146

Morrison, VL, James, MJ, Grzes, K, Cook, P, Glass, DG, Savinko, T, Lek, HS, Gawden-Bone, C, Watts, C, Millington, OR, MacDonald, AS & Fagerholm, SC 2014, 'Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype' Nature Communications, vol. 5, 5359. https://doi.org/10.1038/ncomms6359

Edgar, AJ, Trost, M, Watts, C & Zaru, R 2013, 'A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870' Bioscience Reports. https://doi.org/10.1042/BSR20130094

Cuadrado, E, Jansen, MH, Anink, J, De Filippis, L, Vescovi, AL, Watts, C, Aronica, E, Hol, EM & Kuijpers, TW 2013, 'Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome' Brain, vol. 136, no. 1, pp. 245-258. https://doi.org/10.1093/brain/aws321

Lek, HS, Morrison, VL, Conneely, M, Campbell, PA, McGloin, D, Kliche, S, Watts, C, Prescott, A & Fagerholm, SC 2013, 'The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow' Journal of Biological Chemistry, vol. 288, no. 21, pp. 14698-14708. https://doi.org/10.1074/jbc.M112.430918

Zou, F, Schmon, M, Sienczyk, M, Grzywa, R, Palesch, D, Boehm, BO, Sun, ZL, Watts, C, Schirmbeck, R & Burster, T 2012, 'Application of a novel highly sensitive activity-based probe for detection of cathepsin G' Analytical Biochemistry, vol. 421, no. 2, pp. 667-72. https://doi.org/10.1016/j.ab.2011.11.016

Magister, Š, Obermajer, N, Mirković, B, Švajger, U, Renko, M, Softić, A, Romih, R, Colbert, JD, Watts, C & Kos, J 2012, 'Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells' European Journal of Cell Biology, vol. 91, no. 5, pp. 391-401. https://doi.org/10.1016/j.ejcb.2012.01.001

Watts, C 2012, 'The endosome-lysosome pathway and information generation in the immune system' Biochimica et Biophysica Acta. Proteins and Proteomics, vol. 1824, no. 1, pp. 14-21. https://doi.org/10.1016/j.bbapap.2011.07.006

van Kasteren, SI, Berlin, I, Colbert, JD, Keane, D, Ovaa, H & Watts, C 2011, 'A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function' ACS Chemical Biology, vol. 6, no. 11, pp. 1198-1204. https://doi.org/10.1021/cb200292c

Miller, G, Matthews, SP, Reinheckel, T, Fleming, S & Watts, C 2011, 'Asparagine endopeptidase is required for normal kidney physiology and homeostasis' FASEB Journal, vol. 25, no. 5, pp. 1606-1617. https://doi.org/10.1096/fj.10-172312

Colbert, JD, Matthews, SP, Kos, J & Watts, C 2011, 'Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms' Journal of Biological Chemistry, vol. 286, no. 49, pp. 42082-42090. https://doi.org/10.1074/jbc.M111.253914

Gawden-Bone, C, Zhou, Z, King, E, Prescott, A, Watts, C & Lucocq, J 2010, 'Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14' Journal of Cell Science, vol. 123, no. 9, pp. 1427-1437. https://doi.org/10.1242/jcs.056515

Matthews, SP, Werber, I, Deussing, J, Peters, C, Reinheckel, T & Watts, C 2010, 'Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo' Journal of Immunology, vol. 184, no. 5, pp. 2423-2431. https://doi.org/10.4049/jimmunol.0901486

Mattock, KL, Gough, PJ, Humphries, J, Burnand, K, Patel, L, Suckling, KE, Cuello, F, Watts, C, Gautel, M, Avkiran, M & Smith, A 2010, 'Legumain and cathepsin-L expression in human unstable carotid plaque' Atherosclerosis, vol. 208, no. 1, pp. 83-89. https://doi.org/10.1016/j.atherosclerosis.2009.07.022

Watts, C, West, MA & Zaru, R 2010, 'TLR signalling regulated antigen presentation in dendritic cells' Current Opinion in Immunology, vol. 22, no. 1, pp. 124-130. https://doi.org/10.1016/j.coi.2009.12.005