University of Dundee

Professor Anton Gartner

C. elegans genetics as a model to study basic biological problems
Position: 
Professor of Genetics
Address: 
School of Life Sciences, University of Dundee, Dundee
Full Telephone: 
+44 (0) 1382 385809, int ext 85809
Email: 

Research

Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. Furthermore, we take advantage of the complete genome information and by shared resources of the "worm community".

In response to DNA damage organisms activate checkpoint pathways. In multicellular organisms these pathways lead the activation of DNA repair processes, to a transient cell cycle arrest, or to programmed cell death to eliminate cells that might potentially become harmful for the entire organism.The analysis of the pathways needed for DNA damage sensing, DAN repair and the elucidation of checkpoint responses are currently under intense investigation. We were among the first to use C. elegans to contribute to the understanding of DNA damage dependent apoptosis. Given that genome instability is a major course of human cancers we hope, that in the long run, we might contribute to better tumour-diagnostics and treatment.

Furthermore, we also started to explore C. elegans to uncover molecular mechanisms leading to Parkinson's Disease. Finally we engage in multiple collaborations within the college. Projects include the visualization of key aspects of DNA replication in early C. elegans embryos, and taking full advantage of advanced quantitative mass spectroscopy based approaches.

Teaching

Anton organizes the 3rd year Genetics Course and gives lectures in the 3rd year and 4th years Gene Regulation and Expression modules. Anton also gives presentations for various Dundee PhD programs. Anton is also in charge of PhD students in the centre for Gene Regulation and Expression.

Publications

Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner, LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during cytokinesis, Nature Communications, 2018 Feb 20;9(1):728. doi: 10.1038/s41467-018-03135-w.  PMID:29463814 

Sarah-Lena Offenburger, Xue Yan Ho, Theresa Tachie-Menson, Sean Coakley, Massimo A. Hilliard, Anton Gartner,6-OHDA-induced dopamingeric neurodegeneration in C. elegans is promited by the engulfment pathway and inhibited by the transthyretin-related protein TTF-33. Plos Genetics 2018 Jan 18;14(1):e1007125. doi: 10.1371/journal.pgen.  PMID:29346382  view paper

Sarah-Lena Offenburger, Elisabeth Jongsma, Anton Gartner, Mutations in C. elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopamingeric neurodegeneration after 6-OHDA treatment. Plos Genetics, 2018 Jan 18;14(1):e1007106. doi: 10.1371/journal.pgen.  PMID:29346364  view paper

Meier B, Volkova, N.Hong Y, Schofield P, Campbell PJ, Gerstung M and Gartner A (2017). Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers. bioRxiv, doi:https//doi.org/10.1101/149153, accepted for  Genome Biology

Victor González-Huici, Bin Wang and Anton Gartner, The C. elegans SMG-1 nonsense-mediated mRNA decay pathway is required for survival upon treatment with ionizing irradiation, Genetics 2017, Aug;206(4):1853-1864.  PMID: 28634159   view paper

Sarah-Lena Offenburger, Dalila Bensaddek, Alejandro Brenes Murillo, Angus I. Lamond and Anton Gartner, Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in the development of dopaminergic neurons, Nature Scientific Reports, 2017 Jun 28;7(1):4314.  PMID:28659600 view paper

Federico Pelisch, Triin Tammsalu, Bin Wang, Ellis Jaffray, Anton Gartner and Ronald Hay ‘A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis’ Molecular Cell, 2017 Jan 5;65(1):66-77.  PMID:27939944   view paper

Hong Y, Sonneville R, Agostinho A, Meier B, Wang B, Blow JJ, Gartner A. The SMC-5/6 Complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during Caenorhabditis elegans meiosis. PLoS Genet. 2016 Mar 24;12(3):e1005872. PMID: 27010650. view paper

Yijin Liu, Alasdair D. J. Freeman, Anne-Cécile Déclais, Timothy J. Wilson, Anton Gartner and David M. J. Lilley, Crystal structure of a eukaryotic GEN1 resolving enzyme bound to DNA. Cell Reports, 2015, Dec 22th; 13(11):2565-75.  PMID: 26686639. PMCID:PMC4695337. view paper

Remi Sonneville, Gillian Craig, Karim Labib, Anton Gartner* and J. Julian Blow Linking DNA replication to Chromosome Condensation, Cell Reports, 2015, Jul 21;12(3):405-17 *Co-corresponding author.  PMID:26166571. PMCID: PMC4521082. view paper

Larance M, Pourkarimi E, Wang B, Murillo AB, Kent R, Lamond AI, Gartner A. Global proteomics analysis of the response to starvation in C. elegans. Mol Cell Proteomics. 2015 May 11. pii: mcp.M114.044289.  PMID: 25963834.  PMCID: PMC4587315. view paper

Masoudi N, Ibanez-Cruceyra P, Offenburger SA, Gartner A, Tetraspanin TSP-17 Protects Dopaminergic Neurons against 6OHDA- Induced Neurodegeneration in C. elegans. PloS Genetics, 2014, Dec 4th.  PMID: 25474638. PMCID: PMC4256090. view paper

B. Meier, SL Cooke, J Weiss, AP Bailly, LB Alexandrov, J Marshall, K Raine, M Maddison, E Anderson, MR Stratton, A Gartner*, PC Campbell. C. elegans whole genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res. 2014, Jul 16. pii: gr.175547.114. *Co-corresponding author. PMID: 25030888.  PMCID: PMC4199376. view paper

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, and Hay RT, Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nature Communication, 2014, Dec 5th.  PMID: 25475837. PMCID: PMC4268692. view paper

A Agostinho, B Meier, R Sonneville, M Jagut, A Woglar, J Blow, V Jantsch and A Gartner. Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases. PLoS Genetics, 2013 Jul 9(7): e1003591.  PMCID: PMC3715425. view paper

R Sonneville, M Querenet, A Craig, A Gartner*, JJ Blow. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Journal of Cell Biology, 2012 Jan 23; 196(2): 233-246 *Co-corresponding author.  PMID: 22249291. PMCID:PMC3265957. view paper

M Larance, AP Bailly, E Pourkarimi, RT Hay, G Buchanan, S Coulthurst, DP Xirodimas, A Gartner*, AI Lamond, Stable-isotope labeling with amino acids in nematodes. Nature Methods, 2011 Aug 28;8(10): 849-851 *Co-corresponding author.  PMCID: PMC3184259. view paper

AP Bailly, A Freeman, J Hall, AC Déclais, A Alpi, D Lilley, S Ahmed, A Gartner. The Caenorhabtidis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. PLoS Genetics, 2010 Jul 15;6(7):e1001025.  PMID: 20661466.  PMCID: PMC2908289. view paper

 

Impact

Anton reviewing scientific papers and grant applications approximately once a week, Anton is also engaged with public relations work. He has spoken to many Parkinson’s Disease patients groups to explain basic research done in the field of neurodegeneration. His research was used as the basis of several funding campaigns and also inspired the generation of Dave the worm, a comic figure with presence on Twitter and Facebook explaining research on Parkinson’s disease.  Anton is also involved in an outreach activity at the local Mill Hills observatory, a exhibition open to the public highlighting how basic biomedical research in model organism like C. elegans benefits our understanding of basic biological processes important for health and disease.

Anton is also in charge of organising various Summer Schools in the School of Life Sciences. His ambition is to enable a minimum of 40 undergraduate students from Dundee, but also from further afield, to undertake research placements in the various research laboratories hosted in the School. Anton also advises undergraduate students to help them with Summer Placements outwith Dundee.

Anton hosts high school students and most importantly has set up and leads the GRE summer school. As part of this program  ~12 undergraduate summer students are placed within various GRE laboratories and get hands-on experience by taking part in various scientific projects.  Anton recently also took up responsibilities helping with the BBSC funded PHD program. A recent collaboration with the Sanger Center, that involves large-scale C. elegans sequencing, is at the forefront of developing the next generation of assays for measuring the genotoxicity of known and suspected environmental toxins.  All of Anton's former PhD students are still in science, and two hold independent PI positions in the UK.